Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting.
TLDR
The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway as mentioned in this paper, and the role of mutant p53 as a prognostic factor is recognized, the therapeutic modulation of its wild-type or mutant activities remain a work-in-progress.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2021-04-29 and is currently open access. It has received 107 citations till now.read more
Citations
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Glioma targeted therapy: insight into future of molecular approaches
Keyang Yang,Zhijing Wu,Hao Zhang,Nan Zhang,Wantao Wu,Zeyu Wang,Xun Zhang,Liyang Zhang,Yu Peng,Wei-Jie Ye,Wen-Jing Zeng,Zhixiong Liu,Quan Cheng +12 more
TL;DR: In this article , the authors discuss novel feasible or potential targets for treatment of gliomas, especially IDH-wild type glioblastoma, and evaluate the feasibility of targeted therapy with the corresponding biomarkers for effective personalized treatment options.
Journal ArticleDOI
Glioma targeted therapy: insight into future of molecular approaches
Keyang Yang,Zhijing Wu,Hao Zhang,Nan Zhang,Wantao Wu,Zeyu Wang,Xun Zhang,Liyang Zhang,Yun Peng,Weijie Ye,Wen-Jing Zeng,Zhixiong Liu,Quan Cheng +12 more
TL;DR: In this article , the authors discuss novel feasible or potential targets for treatment of gliomas, especially IDH-wild type glioblastoma, and evaluate the feasibility of targeted therapy with the corresponding biomarkers for effective personalized treatment options.
Journal ArticleDOI
Cell cycle regulation: p53-p21-RB signaling
TL;DR: In this paper , the p53-p21-RB signaling pathway is examined and the mechanism of regulation by p53p21 -RB signaling is assessed and the overlap with p53 p21-DREAM signaling is examined.
Journal ArticleDOI
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
Warren Fiskus,Steffen Boettcher,Naval Daver,Christopher P. Mill,Koji Sasaki,Christine E. Birdwell,John A. Davis,Koichi Takahashi,Tapan M. Kadia,Courtney D. DiNardo,Qi Jin,Yuan Qi,Xiaoping Su,Gerard McGeehan,Joseph D. Khoury,Benjamin L. Ebert,Kapil N. Bhalla +16 more
TL;DR: In this article , the MI-based combinations against AML cells harboring MLL1-r or mtNPM1 were evaluated in a pre-clinical setting, showing that MI treatment with SNDX-5613 and venetoclax achieved superior in vivo efficacy in a cell line or PD AML cell xenografts.
Journal ArticleDOI
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
Warren Fiskus,Steffen Boettcher,Naval Daver,Christopher P. Mill,Koji Sasaki,Christine E. Birdwell,John A. Davis,Koichi Takahashi,Tapan M. Kadia,Courtney D. DiNardo,Qi Jin,Yuan Qi,Xiaoping Su,Gerard McGeehan,Joseph D. Khoury,Benjamin L. Ebert,Kapil N. Bhalla +16 more
TL;DR: In this paper , the MI-based combinations against AML cells harboring MLL1-r or mtNPM1 were evaluated in a pre-clinical setting, showing that MI treatment with SNDX-5613 and venetoclax achieved superior in vivo efficacy in a cell line or PD AML cell xenografts.
References
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Journal ArticleDOI
WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
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CDK inhibitors: positive and negative regulators of G1-phase progression
TL;DR: This work challenges previous assumptions about how the G1/S transition of the mammalian cell cycle is governed, helps explain some enigmatic features of cell cycle control that also involve the functions of the retinoblastoma protein (Rb) and the INK4 proteins, and changes the thinking about how either p16 loss or overexpression of cyclin D-dependent kinases contribute to cancer.
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
TL;DR: In this article, an improved two-hybrid system was employed to isolate human genes encoding Cdk-interacting proteins (Cips) and found that CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2.
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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower,Michele Harvey,Betty L. Slagle,Mark J. McArthur,Charles A. Montgomery,Janet S. Butel,Allan Bradley +6 more
TL;DR: Observations indicate that a normal p53 gene is dispensable for embryonic development, that its absence predisposes the animal to neoplastic disease, and that an oncogenic mutant form of p53 is not obligatory for the genesis of many types of tumours.