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Open AccessJournal ArticleDOI

Plasmablastic Lymphomas of the Oral Cavity: A New Entity Associated With the Human Immunodeficiency Virus Infection

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TLDR
A series of 16 highly malignant diffuse large B-cell lymphomas of the oral cavity with unique immunohistologic features that developed in human immunodeficiency virus-positive patients are reported, and it is proposed to name these tumors plasmablastic lymphomas, in accordance with their morphologic and immunohISTologic features.
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This article is published in Blood.The article was published on 1997-02-15 and is currently open access. It has received 744 citations till now. The article focuses on the topics: Plasmablastic lymphoma & Lymphoma.

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Book ChapterDOI

The World Health Organization Classification of Lymphoid Neoplasms

TL;DR: The World Health Organization classification of the lymphoid neoplasms updated in 2008 represents a worldwide consensus on lymphoma diagnosis and is based in two major principles: the stratification of neoplasm according to their cell lineage and their derivation of precursor or mature cells and the definition of non-overlapping distinct diseases that are clinically relevant.
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Pd-l1 expression is characteristic of a subset of aggressive b-cell lymphomas and virus-associated malignancies

TL;DR: A group of neoplasms associated with aggressive B-cell lymphomas and virus- and immunodeficiency-associated malignancies associated with an ineffective T-cell immune response is identified that should be considered for PD-1/PD-L1-directed therapies, and methods to detect PD-L 1 in FFPE tissue biopsies are validated.

iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns

TL;DR: PReVIously ClAssIfIed by IARC As “CARCInogenIC to humAns (gRoup 1)” And wAs deVeloped by sIx sepARAte woRkIng gRoups: phARmACeutICAls; bIologICAl Agents; ARsenIC, metAls, fIbRes, And dusts; RAdIAtIon; peRsonAl
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Classification of lymphoid neoplasms: the microscope as a tool for disease discovery

TL;DR: The multiparameter approach to classification adopted by the World Health Organization (WHO) classification has been validated in international studies as being highly reproducible and enhancing the interpretation of clinical and translational studies.
References
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Journal ArticleDOI

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

TL;DR: The APAAP technique was found particularly suitable for labeling cell smears and for detecting low numbers of antigen-bearing cells in a specimen and could be used in conjunction with immunoperoxidase methods for double immunoenzymatic staining.
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Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas

TL;DR: A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas.
Journal ArticleDOI

Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and those without HIV infection.

TL;DR: The same herpesvirus-like DNA sequences are present in AIDS-associated Kaposi's sarcoma, classic Kaposi’s sarcomo, and the Kaposi' sarcoma that occurs in HIV-negative homosexual men, suggesting that all three are caused by the same infectious agent.
Journal ArticleDOI

Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease.

TL;DR: Using monoclonal antibody-immune microscopy, it is demonstrated that these two EBV proteins and their associated B-lymphocyte activation or adhesion molecules are expressed in the infiltrating B lymphocytes in immunocompromised patients with EBV lymphoproliferative disease.
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