Journal ArticleDOI
Ultrastructural patterns of RNA synthesis during early embryogenesis of Drosophila melanogaster.
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TLDR
All rRNA loci, whether having complete or incomplete gradients, exhibit high densities of nascent transcripts per unit length, suggesting that the rate of chromatin transcription, rather than the RNA polymarase I pool size, limits rRNA synthesis on individual genes.About:
This article is published in Cell.The article was published on 1976-06-01. It has received 379 citations till now. The article focuses on the topics: RNA & Ribosomal RNA.read more
Citations
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A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage
TL;DR: The Xenopus embryo undergoes 12 rapid synchronous cleavages followed by a period of slower asynchronous divisions more typical of somatic cells, termed the midblastula transition (MBT), which shows that at the MBT the blastomeres become motile and transcriptionally active for the first time.
Journal ArticleDOI
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome.
TL;DR: From the distribution of the allele frequencies and the rate of discovery of new loci, it was estimated that the 61 loci represent the majority of embryonic lethal loci on the second chromosome yielding phenotypes recognizable in the larval cuticle.
Journal ArticleDOI
Transcriptional control signals of a eukaryotic protein-coding gene
TL;DR: Transcriptional control signals of a model eukaryotic protein-coding gene have been identified by a new procedure of in vitro mutagenesis that allows small clusters of nucleotide residues to be substituted in a site-directed manner without causing the addition or deletion of other sequences.
Journal ArticleDOI
Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis
V.E. Foe,B.M. Alberts +1 more
TL;DR: Using differential interference contrast optics, combined with cinematography, the morphological changes that the living, syncytial embryo undergoes from stage 10 through 14 of Drosophila embryogenesis, that is just prior to and during formation of the cellular blastoderm are studied.
Journal ArticleDOI
Inhibition of thymidine kinase gene expression by anti-sense RNA: A molecular approach to genetic analysis
TL;DR: Cells contransformed with flipped TK gene constructions have a reduced capacity to express subsequently microinjected TK genes, suggesting that the anti-message phenomenon is due to a trans-inhibition of TK and is probably not an artifact of rearrangements following microinjection.
References
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Journal ArticleDOI
Inhibition of RNA synthesis by actinomycin D: characteristic dose-response of different RNA species.
Robert P. Perry,Dawn E. Kelley +1 more
TL;DR: Over the range of actinomycin concentrations employed cellular uptake of the drug is proportional to external concentration, and maximal inhibition of RNA synthesis is generally achieved within one hour after exposure.
Journal ArticleDOI
Methylation and processing of ribosomal RNA in HeLa cells
Hanna Greenberg,Sheldon Penman +1 more
TL;DR: The methylation of RNA in HeLa cells has been studied and the previously published hypothesis that nucleolar 45 s RNA is the precursor to cytoplasmic 18 s RNA and 32 s nucleolar RNA is supported.
Journal ArticleDOI
A Molecular Explanation of the Bobbed Mutants of Drosophila as Partial Deficiencies of "Ribosomal" DNA
Journal ArticleDOI
Nucleic acid synthesis in relation to the cell division cycle
TL;DR: By the use of autoradiography and tritium-labeled nucleosides of high speif ic activity, especially with cells in sterile culture, a more critical analysis of the cyclic changes in RNA synthesis is now possible.
Book ChapterDOI
The genetics of embryogenesis in Drosophila.
TL;DR: The purpose of this chapter is to examine how the study of genetic variations that affect embryogenesis in drosophila has in the past contributed, and may in the future contribute, to an understanding of the precise nature of gene action in development.
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Chromosomal subunits in active genes have an altered conformation
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