Journal ArticleDOI
Unravelling the labyrinth of palladium-catalysed reactions involving isocyanides
TLDR
This tutorial review focuses on Isocyanides various applications in chemical synthesis, and the wide range of systems that can be efficiently prepared using this strategy are documented.Abstract:
Isocyanides possess a rich history in the world of synthetic chemistry. Recently the scope of this already versatile class of reagent has been expanded into its use in palladium-catalysed cascade sequences. The scope of this type of reaction is explored in depth and this tutorial review focuses on its various applications in chemical synthesis, and the wide range of systems that can be efficiently prepared using this strategy are documented.read more
Citations
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Recent advances in the synthesis of nitrogen heterocycles via radical cascade reactions using isonitriles as radical acceptors
Bo Zhang,Armido Studer +1 more
TL;DR: A review of recent advances in novel synthetic methods for the construction of nitrogen containing heterocycles highlights recent advances and includes important pioneering studies in this area.
Journal ArticleDOI
Metal-mediated and metal-catalyzed reactions of isocyanides.
Journal ArticleDOI
Formal [4+1] Annulation Reactions in the Synthesis of Carbocyclic and Heterocyclic Systems
Journal ArticleDOI
Overcoming the limitations of directed C–H functionalizations of heterocycles
TL;DR: This operationally simple aerobic reaction demonstrates that it is possible to bypass a fundamental limitation that has long plagued applications of directed C–H activation in medicinal chemistry.
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Synthesis of 6‐Alkylated Phenanthridine Derivatives Using Photoredox Neutral Somophilic Isocyanide Insertion
TL;DR: The first example of photoredox neutral, somophilic isocyanide insertions is reported, which provide 6-alkylated phenanthridine derivatives under mild reaction conditions and is considered to be a new synthetic protocol which circumvents the use of stoichiometric oxidants and harsh reaction conditions.
References
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
Journal ArticleDOI
Palladium-Catalyzed Coupling Reactions of Aryl Chlorides
Adam F. Littke,Gregory C. Fu +1 more
TL;DR: This review summarizes both the seminal early work and the exciting recent developments in the area of palladium-catalyzed couplings of aryl chlorides.
Journal ArticleDOI
Beyond directing groups: transition-metal-catalyzed C-H activation of simple arenes.
TL;DR: In this review, recent advances in the emerging field of non-chelate-assisted C-H activation are discussed, highlighting some of the most intriguing and inspiring examples of induction of reactivity and selectivity.
Journal ArticleDOI
Palladium-catalyzed carbonylation reactions of aryl halides and related compounds.
TL;DR: The recent academic developments in palladium-catalyzed carbonylation reactions of aromatic halides in the presence of various nucleophiles are summarized and the first industrial processes are summarized.
Journal ArticleDOI
C–H functionalization logic in total synthesis
Will R. Gutekunst,Phil S. Baran +1 more
TL;DR: This critical review of C-H functionalization logic will be analyzed through the critical lens of total synthesis, and takes the reader through a series of case studies in which it has already been successfully applied.