Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TLDR
A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.About:
This article is published in Liver Transplantation.The article was published on 2010-08-01. It has received 816 citations till now. The article focuses on the topics: Liver transplantation & Population.read more
Citations
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Journal ArticleDOI
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more
TL;DR: Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.
Philipp Dutkowski,Wojciech G. Polak,Paolo Muiesan,Andrea Schlegel,Cornelia J. Verhoeven,Irene Scalera,Michelle L. DeOliveira,Philipp Kron,Pierre-Alain Clavien +8 more
TL;DR: No graft failure due to intrahepatic cholangiopathy or nonfunction occurred in HOPE-treated livers, whereas 18% of unperfused DCD livers needed retransplantation.
Journal ArticleDOI
New Classification of Donation after Circulatory Death Donors Definitions and Terminology
Marie Thuong,Angel Recio Ruiz,Patrick Evrard,Michael A. Kuiper,Catherine Boffa,M Akhtar,James Neuberger,Rutger J. Ploeg +7 more
TL;DR: Recommendations are presented for uncontrolled and controlled DCD donation and organ specific guidelines for kidney, pancreas, liver and lung transplantation and an expert panel formed a consensus on definitions and terms aiming to establish consistent usage of terms inDCD donation.
Journal ArticleDOI
Hypothermic Machine Preservation Facilitates Successful Transplantation of “Orphan” Extended Criteria Donor Livers
James V. Guarrera,Scot D. Henry,Benjamin Samstein,E. Reznik,C. Musat,T. Lukose,Lloyd E. Ratner,Robert S. Brown,Tomoaki Kato,Jean C. Emond +9 more
TL;DR: Hypothermic machine preservation provided safe and reliable preservation in orphan livers transplanted at the center and was compared to ECD SCS cases in a matched cohort study design.
References
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Journal ArticleDOI
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
TL;DR: A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
Journal ArticleDOI
Simulation Study of Confounder-Selection Strategies
TL;DR: The authors compared the performance of several such strategies for fitting multiplicative Poisson regression models to cohort data, finding that the change-in-estimate and equivalence-test-of-the-difference strategies performed best when the cut-point for deciding whether crude and adjusted estimates differed by an important amount was set to a low value.
Journal ArticleDOI
A review of goodness of fit statistics for use in the development of logistic regression models
Stanley Lemeshow,David W. Hosmer +1 more
TL;DR: Several statistics have recently been proposed for the purpose of assessing the goodness of fit of an estimated logistic regression model and one statistic is recommended for use and its computation is illustrated using data from a recent study of mortality of intensive care unit patients.
Journal ArticleDOI
Characteristics associated with liver graft failure: the concept of a donor risk index.
Sandy Feng,Nathan P. Goodrich,Jennifer L. Bragg-Gresham,Dawn M. Dykstra,J. D. Punch,M. A. DebRoy,S. M. Greenstein,Robert M. Merion +7 more
TL;DR: A quantitative donor risk index was developed using national data from 1998 to 2002 to assess the risk of donor liver graft failure using seven donor characteristics that independently predicted significantly increased risk of graft failure.
Journal ArticleDOI
Risk factors for primary dysfunction after liver transplantation--a multivariate analysis.
Rutger J. Ploeg,Anthony M. D'Alessandro,Stuart J. Knechtle,Mark D. Stegall,John D. Pirsch,Robert M. Hoffmann,Truman M. Sasaki,Hans W. Sollinger,Belzer Fo,Munci Kalayoglu +9 more
TL;DR: Routine donor liver biopsies are recommended to decrease the rate of IPF and PNF, and the combination of risk factors shown to be significant for PDF should be avoided--and the only variable that can be controlled, the preservation time, should be kept as short as possible.
Related Papers (5)
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more