Vertical transmission of hepatitis C virus: a tale of multiple outcomes.
Alejandro Escobar-Gutiérrez,Hugo Soudeyns,Ariane Larouche,Juan Carlos Carpio-Pedroza,Armando Martinez-Guarneros,Carlos A. Vazquez-Chacon,Salvador Fonseca-Coronado,Lílian Hiromi Tomonari Yamasaki,Karina Ruiz-Tovar,Mayra Cruz-Rivera +9 more
Reads0
Chats0
TLDR
The differences in the degree of divergence suggest that the mode of transmission of the virus was not the main factor driving viral evolution, and that immune system dysfunction related to HIV coinfection or persistent HCV seronegativity stand as potential mechanisms to explain the lack of molecular evolution observed.About:
This article is published in Infection, Genetics and Evolution.The article was published on 2013-12-01 and is currently open access. It has received 11 citations till now. The article focuses on the topics: Coinfection & Viral evolution.read more
Citations
More filters
Vertical transmission of hepatitis C virus
TL;DR: Only one of 12 infants showed persistently positive for anti-HCV antibody and HCV RNA at 1, 6 and 12 months of age, suggesting that vertical transmission is present but not an important route for HCV infection.
Journal ArticleDOI
Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.
María Victoria Preciado,Pamela Valva,Alejandro Escobar-Gutiérrez,Paula Rahal,Karina Ruiz-Tovar,Lílian Hiromi Tomonari Yamasaki,Carlos A. Vazquez-Chacon,Armando Martinez-Guarneros,Juan Carlos Carpio-Pedroza,Salvador Fonseca-Coronado,Mayra Cruz-Rivera +10 more
TL;DR: The rapidly evolving field of anti-HCV therapy is expected to broad its landscape even further with newer, more potent antivirals, bringing us one step closer to the interferon-free era.
Journal ArticleDOI
On the use of median-joining networks in evolutionary biology
TL;DR: It is shown that median‐joining networks (MJNs) are theoretically untenable for evolutionary inference, and that confusion has afflicted their use for over 15 years, and the spread of MJNs through the literature is difficult to explain.
Journal ArticleDOI
Hepatitis C in Children Co-infected With Human Immunodeficiency Virus.
TL;DR: The effect of HIV co-infection on HCV-related disease was clear with most studies indicating that HIV accelerates HCV progression and reduces the efficacy of the available anti-HCV therapies.
Journal ArticleDOI
Vertical Transmission of Hepatitis C Virus: Variable Transmission Bottleneck and Evidence of Midgestation In Utero Infection.
Sébastien Fauteux-Daniel,Ariane Larouche,Virginie Calderon,Jonathan Boulais,Chanel Béland,Doris G. Ransy,Marc Boucher,Valérie Lamarre,Normand Lapointe,Isabelle Boucoiran,Armelle Le Campion,Hugo Soudeyns +11 more
TL;DR: A longitudinal assessment of HCV quasispecies diversity and composition in 5 cases of vertical HCV transmission showed that transmission could take place comparatively early in pregnancy, and showed that when the mother also carried human immunodeficiency virus type 1 (HIV-1), many more HCV variants were shared between her and her child, suggesting that the mechanism and/or the route of transmission ofHCV differed in the presence of coinfection with HIV-1.
References
More filters
Journal ArticleDOI
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Kazutaka Katoh,Daron M. Standley +1 more
TL;DR: This version of MAFFT has several new features, including options for adding unaligned sequences into an existing alignment, adjustment of direction in nucleotide alignment, constrained alignment and parallel processing, which were implemented after the previous major update.
Journal ArticleDOI
Median-joining networks for inferring intraspecific phylogenies.
TL;DR: A method for constructing networks from recombination-free population data that combines features of Kruskal's algorithm for finding minimum spanning trees by favoring short connections, and Farris's maximum-parsimony (MP) heuristic algorithm, which sequentially adds new vertices called "median vectors", except that the MJ method does not resolve ties.
Journal ArticleDOI
Replication of hepatitis C virus
TL;DR: The development of complete cell-culture systems should now enable the systematic dissection of the entire viral lifecycle, providing insights into the hitherto difficult-to-study early and late steps.
Journal ArticleDOI
Epidemiology of hepatitis C virus infection
TL;DR: The wave of increased HCV-related morbidity and mortality that the authors are now facing is the result of an unprecedented increase in the spread of HCV during the 20th century, and two 20th Century events appear to be responsible; the widespread availability of injectable therapies and the illicit use of injectables.
Journal ArticleDOI
Epidemiology of hepatitis C virus infection
TL;DR: The high prevalence of anti-HCV detected in HCC suggests that HCV is a major co-factor in the development of HCC and again raises the issue of viral persistence and neoplastic transformation, an issue that for HBV has not yet been elucidated.