Journal ArticleDOI
Wait and see approach for rectal cancer with a clinically complete response after neoadjuvant concurrent chemoradiotherapy.
Hyun Jung Kim,Jin Ho Song,Hyeong Sik Ahn,Bong Hoi Choi,Hojin Jeong,Hoon Choi,Yun Hee Lee,Ki Mun Kang,Bae Kwon Jeong +8 more
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TLDR
Although the W&S approach seemed feasible for rectal cancer patients with a cCR after neoadjuvant CCRT, concrete evidence obtained in well-controlled randomized trials with a long-term follow-up is required to validate potential treatment options.Abstract:
Purpose
Rectal cancer patients with a pathological complete response (pCR) after neoadjuvant concurrent chemoradiotherapy (CCRT) have a better prognosis compared to those without a pCR. Therefore, the “Wait and See” (W&S) approach in those who achieved clinically complete response (cCR) after CCRT was introduced as an alternative modality to the total mesorectal excision (TME). The aim of this study was to compare the oncological outcomes between W&S and TME via meta-analysis.read more
Citations
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Radiation Therapy for Cervical Cancer: Executive Summary of an ASTRO Clinical Practice Guideline
Junzo Chino,Christina M. Annunziata,Sushil Beriwal,Lisa Bradfield,Beth Erickson,Emma C. Fields,Kathryn Jane Fitch,Matthew M. Harkenrider,Matthew M. Harkenrider,Christine H. Holschneider,Mitchell Kamrava,Eric Leung,Lilie L. Lin,Jyoti Mayadev,Marc Morcos,Chika Nwachukwu,Daniel G. Petereit,Akila N. Viswanathan +17 more
TL;DR: This guideline reviews the evidence and provides recommendations for the indications and appropriate techniques of radiation therapy (RT) in the treatment of nonmetastatic cervical cancer and suggests brachytherapy is an essential part of definitive management and volumetric planning is recommended.
Journal ArticleDOI
Wait-and-See Policy for Clinical Complete Responders After Chemoradiation for Rectal Cancer
Tufan Egeli,Aras Emre Canda +1 more
Journal ArticleDOI
Assessing response to neo-adjuvant therapy in locally advanced rectal cancer using Intra-voxel Incoherent Motion modelling by DWI data and Standardized Index of Shape from DCE-MRI.
Antonella Petrillo,Roberta Fusco,Vincenza Granata,Salvatore Filice,Mario Sansone,Daniela Rega,Paolo Delrio,Francesco Bianco,Giovanni Maria Romano,Fabiana Tatangelo,Antonio Avallone,Biagio Pecori +11 more
TL;DR: SIS allows assessment of preoperative treatment response with high accuracy guiding the surgeon versus more or less conservative treatment and no increase of performance was observed by combining linearly each possible couple of parameters or combining all parameters.
Journal ArticleDOI
Morphological and functional features prognostic factor of magnetic resonance imaging in locally advanced rectal cancer
Roberta Fusco,Vincenza Granata,Daniela Rega,Carolina Russo,Ugo Pace,Biagio Pecori,Fabiana Tatangelo,Gerardo Botti,Francesco Izzo,Marco Cascella,Antonio Avallone,Paolo Delrio,Antonella Petrillo +12 more
TL;DR: Lesion vascularization and lymph node number had a predictive value for neoadjuvant treatment complete response in rectal cancer and T2W signal intensity and DWI signal showed a good predictive valueFor local rectal recurrences.
Journal ArticleDOI
Complete response nach Radiochemotherapie des Rektumkarzinoms – was tun?
TL;DR: A watch-and-wait policy in case of complete clinical response following radiochemotherapy for rectal cancer is currently discussed to be critically review on the grounds of recent publications and to compare the results to standard treatment concepts.
References
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Journal ArticleDOI
Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer
Rolf Sauer,Heinz Becker,Werner Hohenberger,Claus Rödel,Christian Wittekind,Rainer Fietkau,Peter Martus,Jörg Tschmelitsch,Eva Hager,Clemens F. Hess,Torsten Liersch,Heinz Schmidberger,Rudolf Raab +12 more
TL;DR: Preoperative chemoradiotherapy, as compared with postoperative cheMoradi therapy, improved local control and was associated with reduced toxicity but did not improve overall survival.
Journal ArticleDOI
Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
Ellen Kapiteijn,Corrie A.M. Marijnen,Iris D. Nagtegaal,Hein Putter,W.H. Steup,Theo Wiggers,Harm J. T. Rutten,Lars Påhlman,Bengt Glimelius,J. Han van Krieken,J.W.H. Leer,Cornelis J.H. van de Velde +11 more
TL;DR: In this article, the authors conducted a multicenter, randomized trial to determine whether the addition of preoperative radiotherapy increases the benefit of total mesorectal excision, and the overall rate of survival at two years among the eligible patients was 82.0 percent in the group assigned to both radiotherapy and surgery.
Journal Article
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
U Tiefenbacher,F Wenz +1 more
Journal ArticleDOI
Mesorectal excision for rectal cancer
TL;DR: Results from TME alone are substantially superior to the best reported from conventional surgery plus radiotherapy or combination chemoradiotherapy: 5% local recurrence at 5 years compared with 25% and 13.5%, respectively; and 22% overall recurrence compared with 62.7% and 41.5, respectively.
Journal ArticleDOI
Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years
Rolf Sauer,Torsten Liersch,Susanne Merkel,Rainer Fietkau,Werner Hohenberger,Clemens F. Hess,Heinz Becker,Hans-Rudolf Raab,Marie-Therese Villanueva,Helmut Witzigmann,Christian Wittekind,Tim Beissbarth,Claus Rödel +12 more
TL;DR: In this paper, the authors reported long-term results with a median follow-up of 134 months, where they found a difference of 10% in 5-year overall survival as the primary end point.
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Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data
Monique Maas,Patty J. Nelemans,Vincenzo Valentini,Prajnan Das,Claus Rödel,Li Jen Kuo,Felipe A. Calvo,Julio Garcia-Aguilar,Rob Glynne-Jones,Karin Haustermans,Mohammed Mohiuddin,Salvatore Pucciarelli,William Small,Javier Suárez,George Theodoropoulos,Sebastiano Biondo,Sebastiano Biondo,Regina G. H. Beets-Tan,Geerard L. Beets +18 more