Journal ArticleDOI
Water distribution in incubated slices of brain and other tissues.
TLDR
With glutamate or high potassium in the medium, swelling is increased and the non-thiocyanate, non-sucrose, and non-inulin spaces increase correspondingly, and this increase is apparently intracellular.Abstract:
Slices of rat cerebral cortex swell about 40% during one hour's aerobic incubation in bicarbonate-buffered medium. Thiocyanate or sucrose added to the medium equilibrate with part of the tissue flu...read more
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Journal ArticleDOI
Dead-space microdomains hinder extracellular diffusion in rat neocortex during ischemia.
TL;DR: The hypothesis that the ischemic increase in λ arises from diffusion delays in newly formed dead-space microdomains of the ECS is hypothesized and offered a novel explanation for the origin of the large λ observed in isChemic brain.
Journal ArticleDOI
Water compartmentalization and extracellular tortuosity after osmotic changes in cerebellum of Trachemys scripta.
TL;DR: The results suggest the use of the isolated turtle cerebellum as a model system for studying light scattering or diffusion‐weighted magnetic resonance imaging.
Journal ArticleDOI
Ionic basis for the depolarization of cerebral tissues by excitatory acidic amino acids.
H. F. Bradford,Henry McIlwain +1 more
TL;DR: Membrane potentials were measured in samples of guinea pig cerebral cortex, before and after small localized additions of neutral solutions of a number of acidic amino acids.
Journal ArticleDOI
Effects of noradrenaline on potassium efflux, membrane potential and electrolyte levels in tissue slices prepared from guinea-pig liver
D. G. Haylett,D. H. Jenkinson +1 more
TL;DR: Some effects of noradrenaline on potassium efflux, electrolyte levels, membrane potential and current distribution in guinea‐pig liver slices have been examined.
Journal ArticleDOI
INTRACELLULAR C1−, Na+, K+, Ca2+, Mg2+, AND P IN NERVOUS TISSUE; RESPONSE TO GLUTAMATE AND TO CHANGES IN EXTRACELLULAR CALCIUM
TL;DR: It is shown that it is possible to isolate and incubate the tissue under control conditions with little or no change in the concentrations of the intracellular electrolytes and to observe how this pattern is affected by changes in Ca2+ or glutamate in the extracellular fluid.
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