Journal ArticleDOI
Water distribution in incubated slices of brain and other tissues.
TLDR
With glutamate or high potassium in the medium, swelling is increased and the non-thiocyanate, non-sucrose, and non-inulin spaces increase correspondingly, and this increase is apparently intracellular.Abstract:
Slices of rat cerebral cortex swell about 40% during one hour's aerobic incubation in bicarbonate-buffered medium. Thiocyanate or sucrose added to the medium equilibrate with part of the tissue flu...read more
Citations
More filters
Journal ArticleDOI
Amino acid metabolism and ammonia formation in brain slices.
H. Weil-Malherbe,J. Gordon +1 more
TL;DR: The formation of ammonia and changes in the contents of free amino acids have been investigated in slices of guinea pig cerebral cortex incubated under the following conditions: aerobically in glucose‐free saline, an inhibitor of glutamate dehydrogenase, and anaerobic in saline.
Journal ArticleDOI
Effects of potassium on indicator spaces and fluxes in slices of brain cortex from adult and new‐born rats
Arne Schousboe,L. Hertz +1 more
TL;DR: Inulin, sucrose and chloride spaces were measured in slices of brain cortex from adult and from new‐born rats incubated in‘balanced', potassium‐rich and sodium‐rich media.
Journal ArticleDOI
Uptake of L-histidine, L-proline, L-tyrosine and L-ornithine by brain, intestinal mucosa, testis, kidney, spleen, liver, heart muscle, skeletal muscle and erythrocytes of the rat in vitro
TL;DR: It appears that L-histidine, L-proline and L-ornithine are taken up to a greater extent by brain than by any of the other tissues investigated, and this difference between uptake by brain and uptake by other tissues in vitro is confined to amino acids with an effect on nervous activity.
Journal ArticleDOI
Development of recent thoughts on intracranial pressure and the blood-brain barrier.
TL;DR: The clinical, physiological, biochemical and histological findings often have seemed inconsistent when one begins dealing with the blood-brain barrier, extracellular brain space, brain swelling.
Book ChapterDOI
The Distribution of Water in Brain Tissues Swollen in vitro and in vivo
TL;DR: Cerebral cortex slices swell appreciably when incubated in vitro in a medium resembling cerebral spinal fluid in its electrolyte composition, and the distribution of water in swollen slices is studied by incorporating thiocyanate, sucrose, inulin, or protein labelled with a fluorescent dye into the incubating medium.
Related Papers (5)
Fluid compartmentation and electrolytes of cat cerebral cortex in vitro–i swelling and solute distribution in mature cerebral cortex*
Robert S. Bourke,Donald B. Tower +1 more