Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression.
TLDR
Exposure of MDA-MB-231 and MCF-7 human breast cancer cells to WA resulted in suppression of XIAP, cIAP-2, and Survivin protein levels, which indicates important contribution of Survivin suppression in WA-induced apoptosis.About:
This article is published in Cancer Letters.The article was published on 2013-06-28 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Survivin & Inhibitor of apoptosis.read more
Citations
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Lead Phytochemicals for Anticancer Drug Development.
TL;DR: Lead phytochemicals with their action mechanisms on nuclear and cellular factors involved in carcinogenesis and druggability parameters and clinical development of anticancer phytomolecules have been discussed.
Journal ArticleDOI
Nanotechnology approaches for personalized treatment of multidrug resistant cancers.
TL;DR: An individualized selection of drugs and targets to suppress multidrug resistance based on the molecular characteristics of a tumor from an individual patient can potentially improve the treatment outcome and bring us closer to an era of personalized medicine.
Journal ArticleDOI
Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action
In-Chul Lee,Bu Young Choi +1 more
TL;DR: This review highlights the mechanistic aspects underlying anticancer effects of withaferin-A, which suppresses experimentally induced carcinogenesis, largely by virtue of its potent anti-oxidative, anti-inflammatory, pro-proliferative and apoptosis-inducing properties.
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Molecular Targets and Mechanisms of Cancer Prevention and Treatment by Withaferin A, A Naturally Occurring Steroidal Lactone
Avani R. Vyas,Shivendra V. Singh +1 more
TL;DR: Cancer-protective role for WA has now been established using chemically-induced and oncogene-driven rodent cancer models, and key in vivo preclinical studies demonstrating anticancer effects of WA are summarized.
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Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
TL;DR: A comprehensive review of the properties of WS extracts (WSE) containing complex mixtures of diverse components including WFA, which have shown inhibitory properties against many cancers, along with their mechanism of actions and pathways involved.
References
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A novel anti-apoptosis gene, survivin , expressed in cancer and lymphoma
TL;DR: It is suggested that apoptosis inhibition may be a general feature of neoplasia and survivin is identified as a potential new target for apoptosis-based therapy in cancer and lymphoma.
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IAP family proteins—suppressors of apoptosis
Quinn Deveraux,John C. Reed +1 more
TL;DR: Although the mechanism used by the IAPs to suppress cell death remains debated, several studies have provided insights into the biochemical functions of these intriguing proteins and a variety of reports have suggested an important role for the I APs in some human diseases.
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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
TL;DR: Whether proteasomes degrade anti-apoptotic molecules in cells induced to undergo apoptosis is examined, and autoubiquitination and degradation of IAPs may be a key event in the apoptotic program.
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The inhibitors of apoptosis (IAPs) and their emerging role in cancer.
Eric C. LaCasse,Stephen Baird,Stephen Baird,Robert G. Korneluk,Robert G. Korneluk,Alex MacKenzie,Alex MacKenzie +6 more
TL;DR: A picture consistent with an IAP role in tumour progression rather than tumour initiation is emerging making the IAPs an attractive therapeutic target.
Journal Article
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
TL;DR: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity, indicating this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects.