Wound healing activity of the ethanol root extract and polyphenolic rich fraction from Potentilla fulgens
Anindita Kundu,Arka Ghosh,Narendra Kumar Singh,Gireesh Kumar Singh,Ankit Seth,Santosh Kumar Maurya,Siva Hemalatha,Damiki Laloo +7 more
TLDR
The present study provided the scientific evidence, where P. fulgens rich in polyphenolic components possess remarkable wound healing activities, thereby supporting the traditional claims.Abstract:
Context: Potentilla fulgens Wall. ex Hook (Rosaceae) is a potent medicinal plant of the Western Himalayas, where its roots are traditionally used by the local people of Uttaranchal (India) to treat wounds and tiger bites.Objective: The present study scientifically evaluates the wound healing activity of P. fulgens ethanol root extract (EPF) and its ethyl acetate fraction (PFEA) on experimental rats.Materials and methods: Wounds were inflicted on animals by using both excision and incision models. The wounded animals were treated for 16 days with EPF (oral: 200–400 mg/kg and topical: 5–10% w/w) and PFEA (oral: 75 mg/kg; topical: 1.75% w/w). Various physical (wound contraction, epithelialization rate, tensile strength) and biochemical parameters (hydroxyproline, hexosamine, proteins, DNA) were examined during the study. Oxidant product (lipidperoxidase), antioxidant enzymes (catalase, superoxide-dismutase) and reduced glutathione were determined. Morphological and histopathological studies of the sk...read more
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Antioxidant and anti-inflammatory properties of Prosopis cineraria based phenolic rich ointment in wound healing.
TL;DR: Results of current study implicate that BFPC has potential to act as effective cutaneous wound healing agent.
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Nano formulated proanthocyanidins as an effective wound healing component
R. Rajakumari,Tatiana G. Volova,Oluwatobi S. Oluwafemi,S Rajeshkumar,Sabu Thomas,Nandakumar Kalarikkal +5 more
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Attenuation of dermal wounds via downregulating oxidative stress and inflammatory markers by protocatechuic acid rich n-butanol fraction of Trianthema portulacastrum Linn. in wistar albino rats
TL;DR: 5% and 10%w/w nBuTP ointment significantly accelerated the wound healing process dose-dependently in both wound models, evidenced by the faster rate of wound contraction, epithelialization, increased hydroxyproline content, high tensile strength, increased antioxidant enzyme activity, decreased the level of inflammatory markers compared to the control group.
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Recent phytochemical and pharmacological advances in the genus Potentilla L. sensu lato - An update covering the period from 2009 to 2020
TL;DR: In vitro studies must be re-considered due to the discovery of urolithins and their origins, including microbiota, which can lead to different results when applying Potentilla species and their extracts to in vivo conditions, so future research should focus more on in vivo studies to confirm the validity and safety of traditional uses.
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Keladi candik (Alocasia longiloba Miq.) petiole extracts promote wound healing in a full thickness excision wound model in rats
Nurul Hazirah Che Hamzah,Arifullah Mohammed,Kns Sirajudeen,Mohd Asnizam Asari,Zulhazman Hamzah,Ibrahim Khalivulla Shaik +5 more
TL;DR: Investigation of the wound-healing effect of Alocasia longiloba petiole extract on wounds in rats showed 6% of 50% and 95% ethanol extracts of A. longilobas have a wound healing potential and 6%.
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