References
More filters
Journal ArticleDOI
Optimal Medical Therapy with or without PCI for Stable Coronary Disease
William E. Boden,Koon K. Teo,Pamela M. Hartigan,David J. Maron,William J. Kostuk,Merril L. Knudtson,Marcin Dada,Paul Casperson,Crystal L. Harris,Bernard R. Chaitman,Leslee J. Shaw,Gilbert Gosselin,Shah Nawaz,Lawrence M. Title,Gerald T. Gau,Alvin Blaustein,David C. Booth,Eric R. Bates,John A. Spertus,Daniel S. Berman,William S. Weintraub +20 more
TL;DR: As an initial management strategy in patients with stable coronary artery disease, PCI did not reduce the risk of death, myocardial infarction, or other major cardiovascular events when added to optimal medical therapy.
Journal ArticleDOI
Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease
Patrick W. Serruys,Marie-Claude Morice,A. Pieter Kappetein,Antonio Colombo,David R. Holmes,Michael J. Mack,Elisabeth Ståhle,Ted Feldman,Marcel van den Brand,Eric Bass,Nic Van Dyck,Katrin Leadley,Keith D. Dawkins,Friedrich W. Mohr,Boston Scientif +14 more
TL;DR: CABG remains the standard of care for patients with three-vessel or left main coronary artery disease, since the use of CABG, as compared with PCI, resulted in lower rates of the combined end point of major adverse cardiac or cerebrovascular events at 1 year.
Journal ArticleDOI
Fractional flow reserve versus angiography for guiding percutaneous coronary intervention
Bernard De Bruyne,Uwe Siebert,Fumiaki Ikeno,Volker Klauss,Ganesh Manoharan,Thomas Engstrøm,Keith G. Oldroyd,Peter N. Ver Lee,Philip MacCarthy,William F. Fearon +9 more
TL;DR: Routine measurement of FFR in patients with multivessel coronary artery disease who are undergoing PCI with drug-eluting stents significantly reduces the rate of the composite end point of death, nonfatal myocardial infarction, and repeat revascularization at 1 year.
Journal ArticleDOI
Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
Bernard De Bruyne,Bindu Kalesan,Emanuele Barbato,Zsolt Piroth,Nikola Jagic,Sven Mobius-Winckler,Gilles Rioufol,Nils Witt,Petr Kala,Philip MacCarthy,Thomas Engstrøm,Keith G. Oldroyd,Kreton Mavromatis,Ganesh Manoharan,Peter Verlee,Ole Fröbert,Nick Curzen,Jane B. Johnson,Peter Jüni,William F. Fearon,Trial Investigators +20 more
TL;DR: In patients with stable coronary artery disease and functionally significant stenoses, FFR-guided PCI plus the best available medical therapy, as compared with the best Available medical therapy alone, decreased the need for urgent revascularization.
Journal ArticleDOI
Optimal Medical Therapy With or Without Percutaneous Coronary Intervention to Reduce Ischemic Burden Results From the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) Trial Nuclear Substudy
Leslee J. Shaw,Daniel S. Berman,David J. Maron,G.B. John Mancini,Sean W. Hayes,Pamela M. Hartigan,William S. Weintraub,Robert A. O'Rourke,Marcin Dada,John A. Spertus,Bernard R. Chaitman,John D. Friedman,Piotr J. Slomka,Gary V. Heller,Guido Germano,Gilbert Gosselin,Peter B. Berger,William J. Kostuk,Ronald G. Schwartz,Merill L Knudtson,Emir Veledar,Eric R. Bates,Benjamin D. McCallister,Koon K. Teo,William E. Boden +24 more
TL;DR: In COURAGE patients who underwent serial MPS, adding PCI to OMT resulted in greater reduction in ischemia compared with OMT alone, and the findings suggest a treatment target of ≥5% ischemic myocardium reduction with O MT with or without coronary revascularization.