Open Access
Xin Scaffolding Proteins and
About:
The article was published on 2013-01-01 and is currently open access. It has received 0 citations till now.read more
References
More filters
Journal ArticleDOI
A Defect in the Kv Channel-Interacting Protein 2 (KChIP2) Gene Leads to a Complete Loss of Ito and Confers Susceptibility to Ventricular Tachycardia
Hai-Chien Kuo,Ching-Feng Cheng,Robert B. Clark,Jim J.-C. Lin,Jenny Li-Chun Lin,Masahiko Hoshijima,Vân T.B. Nguyêñ-Trân,Yusu Gu,Yasuhiro Ikeda,Po-Hsien Chu,John Ross,Wayne R. Giles,Kenneth R. Chien +12 more
TL;DR: It is demonstrated that a defect in KChIP2 is sufficient to confer a marked genetic susceptibility to arrhythmias, establishing a novel genetic pathway for ventricular tachycardia via a loss of the transmural gradient of I(to).
Journal ArticleDOI
Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes
Peter J. Mohler,Ilaria Rivolta,Carlo Napolitano,Guy Lemaillet,Stephen Lambert,Silvia G. Priori,Vann Bennett +6 more
TL;DR: Results in cardiomyocytes suggest that ankyrin-G participates in a common pathway for localization of voltage-gated Na(v) channels at sites of function in multiple excitable cell types.
Journal ArticleDOI
Cellular Basis of Triggered Arrhythmias in Heart Failure
Steven M. Pogwizd,Donald M. Bers +1 more
TL;DR: Overall, the further delineation of key factors that underlie triggered arrhythmias in HF will provide the basis for new therapeutic strategies directed toward novel targets that can reduce the high incidence of sudden death in patients with HF.
Journal ArticleDOI
Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
Igor Kostetskii,Jifen Li,Yanming Xiong,Rong Zhou,Victor A. Ferrari,Vickas V. Patel,Jeffery D. Molkentin,Glenn L. Radice +7 more
TL;DR: This animal model provides the first demonstration of the hierarchical relationship of the structural components of the intercalated disc in the working myocardium, thus establishing N-cadherin’s paramount importance in maintaining the structural integrity of the heart.
Journal ArticleDOI
Differential Expression of Voltage-Gated K+ Channel Subunits in Adult Rat Heart : Relation to Functional K+ Channels?
TL;DR: It seems unlikely that Kv1.4 plays an important role in the formation of functional depolarization-activated K+ channels in adult rat atrial and ventricular myocytes, as indicated by the results of the present study.