YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008.
Fumito Koizumi,Naomi Fukumitsu,Jinrong Zhao,Ruthada Chanklan,Tokichi Miyakawa,Shoko Kawahara,Shin Iwamoto,Makoto Suzuki,Shingo Kakita,Endang Sutriswati Rahayu,Seijiro Hosokawa,Kuniaki Tatsuta,Michio Ichimura +12 more
TLDR
A novel pyrano-pyridone, YCM1008A, suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.Abstract:
In the course of screening for drugs that suppress the Ca(2+)-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca(2+)-signaling. A novel pyrano-pyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca(2+)-induced growth inhibition of the Saccharomyces cerevisiae (Deltazds1Deltasyr1) mutant.read more
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4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches
Henning J. Jessen,Karl Gademann +1 more
TL;DR: A summary of the so far known structures of the 4-Hydroxy-2-pyridone alkaloids, overview the different activities of the compounds and disclose the synthetic attempts since 1982 are given.
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Structural simplification of bioactive natural products with multicomponent synthesis. 2. Antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones
Igor V. Magedov,Igor V. Magedov,Madhuri Manpadi,Marcia A. Ogasawara,Adriana S. Dhawan,Snezna Rogelj,Severine Van slambrouck,Wim F.A. Steelant,Nikolai M. Evdokimov,Pavel Y. Uglinskii,Eerik M. Elias,Erica J. Knee,Paul Tongwa,Mikhail Yu. Antipin,Mikhail Yu. Antipin,Alexander Kornienko +15 more
TL;DR: These heterocyclic libraries are expected to provide promising new leads in anticancer drug design and display low nanomolar antiproliferative activity and induce apoptosis in human cancer cell lines.
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Phylogenetic relationships among members of the Fusarium solani species complex in human infections and the descriptions of F. keratoplasticum sp. nov. and F. petroliphilum stat. nov.
Dylan P. G. Short,Kerry O'Donnell,Ulf Thrane,Kristian Fog Nielsen,Ning Zhang,Jean H. Juba,David M. Geiser +6 more
TL;DR: Primary metabolite profiles of FSSC species defined through molecular data were compared for the first time and revealed the production of bioactive compounds including cyclosporines and several novel compounds of unknown function.
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Synthesis and antioxidant activity of quinolinobenzothiazinones.
TL;DR: A new series of structurally diverse quinolinobenzothiazinones has been synthesized with the annulation of heterocyclic structural pharmacophores and evaluated for their antioxidant and radical scavenging activities.
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Synthesis of novel pyrano[3,2-c]quinoline-2,5-diones using an acidic ionic liquid catalyst
TL;DR: In this article, a three-component reaction between 4-hydroxyquinoline-2-one, Meldrum's acid, and an alkyl or arylaldehyde under catalysis by [Bmim]HSO 4.
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