Journal ArticleDOI
Zwitterionic hydrogels promote skin wound healing
TLDR
Zwitterionic hydrogels exhibit strong hydration, are biomimetic in nature, and show excellent anti-fouling properties; their resulting high water content, excellent biocompatibility, and negligible interactions with proteins and cells make them ideal wet wound dressings.Abstract:
Skin traumas are among the most common health problems in the world, and are routinely treated with wound dressings such as bandages and gauze. Traditional dressings are typically made of dry cotton, which tends to adhere to the wound, causing scab formation and bacterial infections. Ideally, a dressing should accelerate wound healing while avoiding any side effects or complications. Recent studies have found that wet dressings, especially hydrogels, can provide a moist environment for wounds that mimics the in vivo environment, thus facilitating debridement of necrotic tissue, enhancing tissue regeneration, and avoiding scab formation. Zwitterionic hydrogels exhibit strong hydration, are biomimetic in nature, and show excellent anti-fouling properties; their resulting high water content, excellent biocompatibility, and negligible interactions with proteins and cells make them ideal wet wound dressings. In this work, we demonstrated that zwitterionic hydrogels, especially poly-carboxybetaine (PCB) hydrogels, can efficiently promote skin wound healing. Skin wounds treated with zwitterionic hydrogels healed significantly better than those treated with PHEMA hydrogels and the commercial product DuoDerm. Moreover, these zwitterionic hydrogels can be easily coated on cotton gauze or bandage pads for easy handling and application. The findings in this work hold great promise for the development of next-generation wound dressings to improve healthcare.read more
Citations
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Journal ArticleDOI
A Multifunctional Pro-Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment
Yingnan Zhu,Jiamin Zhang,Jiayin Song,Jing Yang,Zheng Du,Weiqiang Zhao,Hongshuang Guo,Chiyu Wen,Qingsi Li,Xiaojie Sui,Lei Zhang +10 more
TL;DR: A multifunctional zwitterionic hydrogel is developed to simultaneously detect two fluctuant wound parameters, pH and glucose level, to monitor the diabetic wound status and guide the diabetes treatment in clinical applications.
Journal ArticleDOI
Recent Progress of Highly Adhesive Hydrogels as Wound Dressings.
TL;DR: The recent advances in developing hydrogel-based wound dressings as well as their adhesion mechanism are summarized and the progress prospects over the coming years were covered.
Journal ArticleDOI
Zwitterionic polymers and hydrogels for antibiofouling applications in implantable devices
TL;DR: A critical review of zwitterionic materials carrying permanent positive and negative charges, but displaying an overall charge neutrality for antibiofouling applications is provided.
Journal ArticleDOI
One-step synthesis of an antibacterial and pro-healing wound dressing that can treat wound infections.
TL;DR: A novel wound dressing based on a zwitterionic polycarboxybetaine (PCB) hydrogel and antibacterial silver nanoparticles (AgNPs) was developed via a one-step method for the efficient treatment of infected wounds and can promote the reconstruction of intact epidermis.
Journal ArticleDOI
Mechano-Responsive, Tough, and Antibacterial Zwitterionic Hydrogels with Controllable Drug Release for Wound Healing Applications.
Kun Fang,Kun Fang,Rong Wang,Hua Zhang,Linjie Zhou,Ting Xu,Ying Xiao,Yang Zhou,Guorong Gao,Jing Chen,Donglei Liu,Fanrong Ai,Jun Fu +12 more
TL;DR: A mechano-responsive poly(sulfobetaine methacrylate) hydrogel which aims to control the delivery of antibiotic drug upon application of mechanical forces is developed and shows great promise as wound dressings for acute wounds subjected to frequent movements.
References
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Journal ArticleDOI
Wound healing dressings and drug delivery systems: a review.
TL;DR: The requirement for formulations with improved properties for effective and accurate delivery of the required therapeutic agents and general formulation approaches towards achieving optimum physical properties and controlled delivery characteristics for an active wound healing dosage form are considered.
Journal ArticleDOI
Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications
Shaoyi Jiang,Zhiqiang Cao +1 more
TL;DR: Mixed-charge materials have been shown to be equivalent to zwitterionic materials in resisting nonspecific protein adsorption when they are uniformly mixed at the molecular scale.
Journal ArticleDOI
Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Lei Zhang,Zhiqiang Cao,Tao Bai,Louisa R. Carr,Jean-Rene Ella-Menye,Colleen Irvin,Buddy D. Ratner,Shaoyi Jiang +7 more
TL;DR: Zwitterionic hydrogels can resist the formation of a capsule for at least 3 months after subcutaneous implantation in mice, and may be useful in a broad range of applications, including generation of biocompatible implantable medical devices and tissue scaffolds.
Journal ArticleDOI
Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing
Guoming Sun,Xianjie Zhang,Yu-I Shen,Raul Sebastian,Laura E. Dickinson,Karen Fox-Talbot,Maura Reinblatt,Charles Steenbergen,John W. Harmon,Sharon Gerecht +9 more
TL;DR: Customized dextran-based hydrogel alone, with no additional growth factors, cytokines, or cells, promoted remarkable neovascularization and skin regeneration and may lead to novel treatments for dermal wounds.
Journal ArticleDOI
Hydrogel blends of chitin/chitosan, fucoidan and alginate as healing-impaired wound dressings.
Kaoru Murakami,Hiroshi Aoki,Shingo Nakamura,Shin-ichiro Nakamura,Megumi Takikawa,Motoaki Hanzawa,Satoko Kishimoto,Hidemi Hattori,Yoshihiro Tanaka,Tomoharu Kiyosawa,Yasunori Sato,Masayuki Ishihara +11 more
TL;DR: Histological examination demonstrated significantly advanced granulation tissue and capillary formation in the healing-impaired wounds treated with ACF-HS on day 7, as compared to those treated with calcium alginate fiber and those left untreated.
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Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications
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