How do epigenetic regulators in T helper cells and cytokine secreted by T helper cells contribute to intestinal inflammation?
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Epigenetic regulators in T helper cells and cytokines secreted by T helper cells play crucial roles in intestinal inflammation. T helper cell differentiation and plasticity are controlled by cytokine networks and transcriptional regulators, allowing them to adapt to different physiological environments . Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by dysregulated immune responses against commensal microbiota, which involves the activation of CD4 T helper cells . The effects of tissue alarmins, such as interleukin (IL)-15 and interferon beta (IFNβ), and IL-21 produced by T cells on the reprogramming of cytotoxic T lymphocytes (CTLs) in celiac disease have been investigated . Metabolic and epigenetic remodeling, specifically polyamine metabolism, have been found to direct T helper cell lineage choices, epigenetic state, and pathogenic potential in inflammation . Additionally, CD4+ T cells have been implicated in both the suppression and promotion of intestinal inflammation, and their heterogeneity and dynamic responses contribute to colorectal cancer progression . Furthermore, targeting the enzyme acetyl-CoA carboxylase 1 (ACC1), which controls fatty acid synthesis, has been shown to impair intestinal Th1 and Th17 responses, highlighting the role of metabolic immune modulation in T-cell-driven intestinal inflammatory responses .
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| Epigenetic regulators in T helper cells and cytokines secreted by T helper cells contribute to intestinal inflammation by inducing transcriptional changes in cytotoxic T lymphocytes. | |
6 Citations | Epigenetic regulators and cytokines secreted by T helper cells contribute to intestinal inflammation by influencing cell fate and pathogenic potential. |
| Epigenetic regulators and cytokines secreted by T helper cells play a role in intestinal inflammation in inflammatory bowel disease (IBD). |
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