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Iris Jonkers
Researcher at University Medical Center Groningen
Publications - 42
Citations - 3625
Iris Jonkers is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: X-inactivation & Gene. The author has an hindex of 20, co-authored 35 publications receiving 2892 citations. Previous affiliations of Iris Jonkers include Cornell University & Erasmus University Rotterdam.
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Journal ArticleDOI
Getting up to speed with transcription elongation by RNA polymerase II
Iris Jonkers,John T. Lis +1 more
TL;DR: Elongation is recognized as a key phase in the regulation of transcription by Pol II, revealing that elongation is a highly complex process.
Journal ArticleDOI
Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
TL;DR: Notably, Pol II accelerates dramatically while transcribing through genes, but slows at exons, and intergenic variance in elongation rates is substantial, and is influenced by a positive effect of H3K79me2 and negative effects of exon density and CG content within genes.
Journal ArticleDOI
Disease variants alter transcription factor levels and methylation of their binding sites.
Marc Jan Bonder,René Luijk,Daria V. Zhernakova,Matthijs Moed,Patrick Deelen,Martijn Vermaat,Maarten van Iterson,Freerk van Dijk,Michiel van Galen,Jan Bot,Roderick C. Slieker,P. Mila Jhamai,Michael Verbiest,H. Eka D. Suchiman,Marijn Verkerk,Ruud van der Breggen,Jeroen van Rooij,Nico Lakenberg,Wibowo Arindrarto,Szymon M. Kielbasa,Iris Jonkers,Peter van ‘t Hof,Irene Nooren,Marian Beekman,Joris Deelen,Diana van Heemst,Alexandra Zhernakova,Ettje F. Tigchelaar,Morris A. Swertz,Albert Hofman,André G. Uitterlinden,René Pool,Jenny van Dongen,Jouke J. Hottenga,Coen D.A. Stehouwer,Carla J.H. van der Kallen,Casper G. Schalkwijk,Leonard H. van den Berg,Erik W. van Zwet,Hailiang Mei,Yang Li,Mathieu Lemire,Thomas J. Hudson,Thomas J. Hudson,P. Eline Slagboom,Cisca Wijmenga,Jan H. Veldink,Marleen M.J. van Greevenbroek,Cornelia M. van Duijn,Dorret I. Boomsma,Aaron Isaacs,Aaron Isaacs,Rick Jansen,Joyce B. J. van Meurs,Peter A C 't Hoen,Lude Franke,Bastiaan T. Heijmans +56 more
TL;DR: It is shown that disease-associated variants have widespread effects on DNA methylation in trans that likely reflect differential occupancy of trans binding sites by cis-regulated transcription factors.
Journal ArticleDOI
Base-pair-resolution genome-wide mapping of active RNA polymerases using precision nuclear run-on (PRO-seq)
Dig Bijay Mahat,Hojoong Kwak,Gregory T. Booth,Iris Jonkers,Charles G. Danko,Ravi K. Patel,Colin T. Waters,Colin T. Waters,Katie Munson,Leighton J. Core,Leighton J. Core,John T. Lis +11 more
TL;DR: A protocol for precision nuclear run-on sequencing (PRO-seq) and its variant, PRO-cap, which map the location of active RNA polymerases or transcription start sites (TSSs) genome-wide at highresolution at high resolution is provided.
Journal ArticleDOI
RNF12 Is an X-Encoded Dose-Dependent Activator of X Chromosome Inactivation
Iris Jonkers,Tahsin Stefan Barakat,Eskeatnaf Mulugeta Achame,Kim Monkhorst,Annegien Kenter,Eveline Rentmeester,Frank Grosveld,J. Anton Grootegoed,Joost Gribnau +8 more
TL;DR: Evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process is provided, which is dependent on an intact open reading frame of Rnf12 and correlates with the transgenic expression level of R NF12.