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Fenugreek seeds showed excellent functional properties.
This is the first report describing the phytochemical composition of germinated fenugreek seeds.
In conclusion, the defatted portion of fenugreek seed induces a hypocholesterolaemic effect.
It appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum Apelin.
This study reveals significant antioxidant activity in germinated fenugreek seeds which may be due partly to the presence of flavonoids and polyphenols.
In conclusion, the results indicated that fenugreek seeds ameliorated the cytotoxicity and testicular alterations induced by ADR in albino rats and this may be mediated by its potent antioxidant effects.
The present novel report on the antioxidant influence of fenugreek seeds in conditions of oxidative stress brought about in hypercholesterolemia and lithogenic situation has an implication in deriving human health benefit of this spice adjuvant.

Related Questions

How does the consumption of roasted fenugreek seed powder affect blood glucose levels in individuals with type-II diabetes?5 answersConsumption of roasted fenugreek seed powder has shown promising effects on blood glucose levels in individuals with type-II diabetes. Studies have highlighted that fenugreek seed powder, when added to the diet, leads to a reduction in blood glucose levels over time. Additionally, research has demonstrated that fenugreek seeds possess hypoglycemic properties, inhibiting α-amylase activity and reducing blood glucose levels in diabetic mice. Furthermore, the anti-hyperlipidemic properties of fenugreek can also contribute to managing lipid-related conditions like obesity and prediabetes, which are often associated with diabetes. Therefore, incorporating roasted fenugreek seed powder into the diet may help in controlling blood glucose levels and improving overall lipid profiles in individuals with type-II diabetes.
Is fenugreek extract better than single constituent in treating cancer?5 answersFenugreek extract has shown promising anti-cancer properties compared to single constituents. Studies have highlighted that fenugreek extracts contain various bioactive compounds like flavones, isoflavones, saponins, and fibers. These compounds have demonstrated cytotoxic, antiproliferative, and anti-angiogenic effects on cancer cells, including breast cancer cells. Additionally, fenugreek extracts have been found to induce apoptosis and autophagy in leukemia cells, showcasing their potential in cancer treatment. The synergistic effects of multiple constituents in fenugreek extracts seem to offer a more comprehensive approach to combating cancer by targeting various pathways simultaneously, which may be more effective than relying on a single constituent alone.
What is the relation between fenugreek and cancer?5 answersFenugreek, scientifically known as Trigonella foenum-graecum, exhibits promising anti-cancer properties against various types of cancer, including breast cancer, colorectal cancer, hepatocellular carcinoma, and pancreatic cancer. Studies have shown that fenugreek extracts and compounds derived from fenugreek seeds and sprouts possess cytotoxic, antiproliferative, and apoptosis-inducing effects on cancer cells. These effects are attributed to the presence of bioactive phytochemicals like flavones, isoflavones, and proteins in fenugreek, which contribute to inhibiting cancer cell growth, inducing apoptosis, and reducing metastasis. Additionally, fenugreek has been found to modulate various cellular processes, including mitochondrial function, ROS generation, and apoptotic signaling pathways, making it a potential natural resource for developing anti-cancer therapies across different types of cancer.
How can fenugreek seed mucilage be extracted?5 answersFenugreek seed mucilage can be extracted by isolating it from the seeds of Trigonella Foenum-graecum, commonly known as Fenugreek. The extraction process involves evaluating the flow properties, pH value, FTIR spectroscopy, and percentage practical yield of the mucilage. The mucilage can then be used to formulate solid dispersions with different drug to polymer ratios, such as hydroxy propyl methyl cellulose (HPMC). Saturation solubility tests can be conducted on the fenugreek seed mucilage solid dispersion (FSMSD), hydroxy propyl methyl cellulose solid dispersion (HPMCSD), and pure drug to determine the formulation with the highest solubility. Tablets can be prepared from the solid dispersion with the highest solubility, which can then be tested and evaluated for physicochemical properties, disintegration time, hardness, and drug release. Overall, fenugreek seed mucilage shows promise as an excipient for enhancing the solubility of low soluble drugs.
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