Showing papers on "Aphanamixis published in 2013"
TL;DR: From the fruits of the tropical tree Aphanamixis grandifolia, five new evodulone-type limonoids, aphanalides I-M, one new apo-tirucallane-type triterpenoid, polystanin E, and three new chain-like diterpenoids, nemoralisins A-C, along with 12 known compounds were identified.
Abstract: From the fruits of the tropical tree Aphanamixis grandifolia, five new evodulone-type limonoids, aphanalides I–M (1–5), one new apo-tirucallane-type triterpenoid, polystanin E (6), and three new chain-like diterpenoids, nemoralisins A–C (7–9), along with 12 known compounds were identified. The absolute configurations were determined by a combination of single-crystal X-ray diffraction studies, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, the Mosher ester method, and calculated ECD data. The cytotoxicities of all the isolates and the insecticidal activities of the limonoids were evaluated.
44 citations
TL;DR: Within the series of phytosterol derivatives tested, compound 15 was the most active, displaying potent cytotoxicity against HL-60 with IC(50) of 5.10μmol/L, and most of the active compounds showed selective cytot toxicity against tumor and non-tumor cell lines, especially compound 10 with a safety index of 4.42.
37 citations
TL;DR: One new sterol, (3β,21α,22a)-stigmast-5-ene-3,21,22-triol (1), together with 36 compounds, were isolated from the stems of Aphanamixis grandifolia.
Abstract: One new sterol, (3β,21α,22a)-stigmast-5-ene-3,21,22-triol (1), together with 36 compounds (2–37), were isolated from the stems of Aphanamixis grandifolia. The structure of 1 was elucidated by physical, chemical, and spectroscopic methods, including 1D and 2D NMR and HR-ESI-MS. Besides, 33 compounds (2, 4, 5, 7–10, 12–30, and 32–37) were isolated from the Aphanamixis genus for the first time, and 15 was isolated from the plant for the first time.
31 citations
TL;DR: Aphanamgrandiol A showed moderate cytotoxicities against MCG-803, SKOV-3, HCT116 and HepG2 cell lines and was established on the basis of extensive spectroscopic methods, including 1D and 2D NMR techniques, and determined unambiguously by X-ray crystal diffraction.
25 citations
TL;DR: Three new cycloartane triterpenoids, aphagrandinoids A-C, and a new natural product, aphgrandinoid D, together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia and their structures were elucidated by extensive NMR and MS techniques.
24 citations
TL;DR: Two unprecedented acyclic diterpene dimers formed via a [4 + 2]-cycloaddition were isolated from the root bark of Aphanamixis grandifolia and showed significant inhibition on NO production on lipopolysaccharide-induced RAW264.7 macrophages.
19 citations
TL;DR: A review of triterpenoids isolated from Aphanamixis plants and their bioactivities, structure-activity relationships and biosyntheses is presented in this article, where the authors focus on the production of complex, highly oxidised tetranortriterpenoids (also known as limonoids or meliacins).
Abstract: Members of the Meliaceae family have been studied extensively because they contain a series of interesting, structurally diverse and biologically important triterpenoids. Plants from the genus Aphanamixis of Meliaceae have a long history of medicinal use. Substantial investigations into their chemical and pharmacological properties have been performed. Recently, interest in this genus has been centred on their production of complex, highly oxidised tetranortriterpenoids (also known as limonoids or meliacins), which exhibit potent cytotoxic and antitumour activities against various human cancer cell lines and in preclinical animal models. This review summarises triterpenoids isolated from Aphanamixis plants and those triterpenoids’ bioactivities, structure–activity relationships and biosyntheses.
12 citations
TL;DR: Two new limonoids aphanamolides C (1) and D (2), together with two known limonoid A (3) and aphapolynin A (4), were isolated from the fruits of Aphanamixis grandifolia as mentioned in this paper.
9 citations
TL;DR: Aphagranols A (1 ) and B (2 ) were isolated from the fruits of Aphanamixis grandifolia and their structures were determined by spectroscopic analyses and further confirmed by their unique acetylated derivative aphagranol C (3 ) as discussed by the authors.
5 citations