Showing papers on "Derivative (chemistry) published in 1973"
TL;DR: The reaction of p-hydroxybenzoic acid hydrazide and reducing carbohydrates in alkaline solution can be used in colorimetric and fluorometric assay procedures that are capable of determining glucose at concentrations from less then 0.1 μg/ml up to levels found in human serum.
213 citations
TL;DR: The 1α-hydroxy derivative of vitamin D3 has been chemically synthesized and tested for its biological activity as discussed by the authors, which has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D3 in the stimulation of intestinal calcium transport and bone calcium mobilization in normnal and anephric rats.
Abstract: The 1α-hydroxy derivative of vitamin D3 has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D3 in the stimulation of intestinal calcium transport and bone calcium mobilization in normnal and anephric rats. Because the 1α-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1α,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypopara-thyroidism.
174 citations
TL;DR: In this paper, a liquid crystal material which at least contains a compound having a molecular structure such that the material exhibits a liquid-crystal phase, the molecular structure of the compound being selected from one of the following structures: the structure, a simple ortho-substituted derivative of the structure, and a derivative in which a simple bridging group is contained between two of the orthopositions of the said structure wherein X and Y are different parasubstituents of the kind which promote liquid crystal behaviour.
Abstract: OF THE DISCLOSURE A liquid crystal material which at least contains a compound having a molecular structure such that the material exhibits a liquid crystal phase, the molecular structure of the compound being selected from one of the following structures: the structure ; a simple ortho-substituted derivative of the structure ; and a derivative of the structure in which a simple bridging group is contained between two of the ortho-positions of the said structure wherein X and Y are different para-substituents of the kind which promote liquid crystal behaviour, the para-substituent X being a group selected from the following list: an alkoxy group having more than one carbon atom; an alkyl group; an acyloxy group; and an alkenyl group; and the para-substituent Y being selected from the following list: a cyano group; a benzene ring substituted in the para-position by a cyano group; and a plurality of directly para-linked benzene rings in which the end ring remote from the substituent X is substituted in the para-position by a cyano group. The material may be the said compound or it may be a multi-component solution or mixture containing it. The liquid crystal material may be nematic, smectic or cholesteric depending on the selection of the substituents X and Y. A device such as a twisted nematic effect device, incorporating the material may be operated at low temperatures. The material does not suffer from significant chemical and/or photochemical decomposition when used in a liquid crystal device.
146 citations
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141 citations
TL;DR: On the basis of the spectral characteristics of a synthetic compound, it is suggested that the bromopyrrole derivative oroidin, isolated from marine sponge, be reassigned structrue as mentioned in this paper.
Abstract: On the basis of the spectral characteristics of a synthetic compound (4) it is suggested that the bromopyrrole derivative oroidin, isolated from marine sponge, be reassigned structrue (3).
103 citations
TL;DR: In this article, the photochemical transformation of a 1,3,5-hexatriene derivative to a bicyclo[3.2]hex-2-ene has been shown to proceed from an s-trans,s-cis conformation.
Abstract: The photochemical transformation of the 1,3-cyclohexadiene chromophore can lead via orbital symmetry allowed pathways either to a bicyclo[2.2.Olhex-2-ene derivative or to a 1,3,5-hexatriene derivative. It was established that the ground state conformation of the starting 1 ,3-cyclohexadiene controls the primary photochemical reaction. The photoproducts composition can be changed by variation of the wavelength or of the temperature. The mechanisms of these processes are discussed. The photochemical transformation of a 1 ,3,5-hexatriene derivative to a bicyclo[3. 1 .O]hex-2-ene has been shown to proceed from an s-trans ,s-cis conformation. The mechanism of the rearrangement has been shown to be an extension of the rearrangement of a 1,3-butadiene to a bicyclo[l .1.O]butane. In the study of the photochemistry of 1,3-cyclohexadienes, the evaluation of the photoequilibrium between the diene and the resultant triene is important t National Institute of Health Predoctoral Fellow. National Science Foundation Predoctoral Fellow. R = Ii = 0.02 = 0.4_ cl = 0.1
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73 citations
Patent•
13 Dec 1973TL;DR: In this article, the reaction of elemental nickel with the MZ3 ligand at a temperature in the range of 0 DEG C-150 DEGC in the presence of a halogen containing derivative of MZ 3 as a catalyst is described.
Abstract: Zerovalent nickel complexes of the types Ni(MZ3)4 and Ni(MZ3)2A; wherein M is P, As or Sb, Z is R or OR, R is an alkyl or aryl radical having up to 18 carbon atoms and may be the same or different, and at least one Z is OR, A is a monoolefinic compound having 2 to 20 carbon atoms, the R radicals of a given MZ3 of Ni(MZ3)2A preferably being so chosen that the ligand has a cone angle of at least 130 DEG ; are prepared by reacting elemental nickel with the MZ3 ligand at a temperature in the range of 0 DEG C.-150 DEG C. in the presence of a halogen containing derivative of MZ3 as a catalyst. A more rapid reaction is realized by carrying out the preparation in an organonitrile solvent.
Patent•
15 Feb 1973
TL;DR: In this article, the authors describe compositions, particularly edible compositions, oral compositions and flavor compositions, containing a compound imparting a cooling sensation, said compound being a hydroxymethyl or hydroxyethyl derivative of para-menthane.
Abstract: Compositions, particularly edible compositions, oral compositions and flavor compositions, containing a compound imparting a cooling sensation, said compound being a hydroxymethyl or hydroxyethyl derivative of para-menthane, for example 2-hydroxymethylmenthol.
Patent•
26 Jan 1973
TL;DR: Cografted copolymers of polyolefins as mentioned in this paper have at least one polymerizable acyclic, cyclic or polycyclic ethylenically unsaturated acid or acid anhydride monomer.
Abstract: Cografted copolymers of polyolefins, at least one polymerizable acyclic, cyclic or polycyclic ethylenically unsaturated acid or acid anhydride monomer and at least one polymerizable conjugated ethylenically unsaturated ester monomer. These cografted copolymers exhibit superior performance in composites, blends and chemically reacted derivative products when compared with unmodified polyolefins and polyolefins grafted with only one of these monomers.
TL;DR: Pyrolysis and gas-liquid chromatography of the hydroxyacids showed that labeled palmitate was incorporated equally into the mero-aldehyde and carboxyl terminal moieties of the molecule.
TL;DR: Based on results, the following reaction path for substituted 2-amino-4(3H)-pteridones seems likely: in neutral and slightly alkaline solution the first step is a reversible two-electron reduction to the unreducible 5,8-dihydro derivative, which tautomerizes into a reducible 6,7- dihydropteridone at a rate depending on the substituents.
TL;DR: In this article, the problem of electron-excited Auger analysis resulting from chemical alteration of the shapes of the characteristic features can be virtually eliminated by integration techniques, and these techniques recover the signal strength lost by taking data derivative modes.
TL;DR: The titanous and titanic complexes of the water-insoluble poly(N-acryloyl-4- and -5-aminosalicylic acids) have been prepared by several methods as discussed by the authors.
Patent•
17 Dec 1973
TL;DR: In this article, a color-forming composition and recording sheets embodying the composition are disclosed, wherein the colorforming composition comprises: (a) a leuco dye, (b) an aromatic secondary amine or derivative thereof and (c) an organic solvent.
Abstract: A color-forming composition and recording sheets embodying the composition are disclosed, wherein the color-forming composition comprises: (a) a leuco dye, (b) an aromatic secondary amine or derivative thereof and (c) an organic solvent.
TL;DR: In this paper, the same β-elimination reaction was applied to thermolysis and photolysis of alkylcobaloximes RCH(R′)R″H and cobaloxime(I) hydride HCo(DMG) 2 Py in the absence of oxygen.
TL;DR: In this article, 1α-hydroxycholesterol (4a) was synthesized from cholesterol and transformed via its diacetyl derivative 4b into 1α, 3β-diacetoxycholesta-5, 7-diene (6b).
Abstract: 1α-hydroxycholesterol (4a) was synthesized from cholesterol and transformed via its diacetyl derivative 4b into 1α, 3β-diacetoxycholesta-5, 7-diene (6b). Irradiation of the ring-B-diene 6b followed by thermal isomerization and saponification gave 1α-hydroxycholecalciferol (7).
TL;DR: In this paper, two new flavones, semiglabrinol and semigabrin, have been isolated from Tephrosia semigLabra Sond. and their structures have been established as 2.
TL;DR: In this paper, the reactions of π-cyclopentadienylnickel carbonyl dimer with 3,3,3-trimethylpropynyldiphenylphosphine and phenylethynyldeplinylphophosphine are described and the products have been characterized by elemental and mass spectral analysis, infrared and NMR spectroscopy.
Patent•
26 Apr 1973
TL;DR: In this article, the authors developed a picture-developing-out PHOTOSENSITIVE MATERIALS consisting of a support, and a lidar support, as well as a bundler, a REDUCING AGENT, ASCORBIC ACID, or a 3-PYRAZOLIDONE DERIVATIVE.
Abstract: HEAT DEVELOPING-OUT PHOTOSENSITIVE MATERIALS CONSISTING OF THE FOLLOWING COMPONENTS: (A) A SUPPORT, AND (B) A LAYER COMPRISING THE FOLLOWING INGREDIENTS: (1) SILVER BENZOTRIAZOLE, (2) A SILVER HALIDE OBTAINED BY THE REACTION OF SIL VER BENZOTRIAZOLE AND AN INORGANIC HALIDE, (3) AS A REDUCING AGENT, ASCORBIC ACID, A DERIVATIVE THEREOF OR A 3-PYRAZOLIDONE DERIVATIVE (4) A BINDER, AND (5) A COMPOUND OF THE FORMULA 3-(HS-),4-R1,5-R2-1,2,4-TRIAZOLE WHEREIN R1 REPRESENTS HYDROGEN OR ALKYL GROUP OR A GROUP OF THE FORMULA R3-PHENYL R2 REPRESENTS AN ALKYL GROUP OR A GROUP OF THE FORMULA R3-PHENYL AND R3 STANDS FOR HYDROGEN OR AN OMINO GROUP OF A GROUP OF THE FORMULA -NH-CO-R4 AND R4 STANDS FOR AN ALKYL GROUP.
TL;DR: A serial dilution assay showed the title compound and the 4-methyl derivative to have antimicrobial activity against Gram-positive bacteria, yeasts, and molds.
TL;DR: Structure 1 has been elucidated for chaenorhine, an alkaloid isolated from Chaenorhinum organifolium (Scrophulariaceae), and 21 gave upon hydrolysis spermine and 4-hydroxydihydrocinnamic acid characterized as the tetraacetyl derivative 18 and as the dimethyl derivative respectively.
Abstract: Structure 1 has been elucidated for chaenorhine, an alkaloid isolated from Chaenorhinum organifolium (Scrophulariaceae). The key derivative for the structural elucidation is 13,14,21,22-tetrahydro-21,22-seco-chaenorhine (21). 21 gave upon hydrolysis spermine and 4-hydroxydihydrocinnamic acid characterized as the tetraacetyl derivative 18 and as the dimethyl derivative respectively.
TL;DR: In this article, the reaction of lithium metal surfaces with optically active 1-halo-1-methyl-2,2-diphenylcyclopropane leads to the formation of the corresponding lithium derivative which is partially racemized.
TL;DR: The synthesis of 3-methylisoxazolo[4,5-b]pyrazine and its 7-oxide was reported in this article, where Nitration of 6 furnished the 6-nitro derivative, while reaction with phosphoryl chloride provided the chloro derivative.
Patent•
21 Aug 1973
TL;DR: In this paper, a physiologically acceptable insulin derivative is obtained from porcine or bovine insulin by reacting the insulin with an acylating agent or other blocking reagent to acylate or otherwise block the amino group of the B1 amino acid and optionally block the A1 and/or B29 amino acid.
Abstract: A physiologically acceptable insulin derivative has the terminal amino group of the B chain (B1, phenylalanine) protected by an acyl group or other blocking group containing up to seven carbon atoms and the amino group of the A chain (A1, glycine) is either free or protected by means of an acyl or other blocking group containing no more than four carbon atoms and preferably no more than three atoms other than hydrogen. Pharmaceutical preparations may be prepared containing an effective amount of such an insulin derivative together with a physiologically acceptable diluent. An insulin derivative of reduced antigenicity is obtainable from porcine or bovine insulin by reacting the insulin with an acylating agent or other blocking reagent to acylate or otherwise block the amino group of the B1 amino acid and optionally block the A1 and/or B29 amino acid, followed by purification of the derivative by various methods.