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A. Sloan Devlin
Researcher at Harvard University
Publications - 28
Citations - 8832
A. Sloan Devlin is an academic researcher from Harvard University. The author has contributed to research in topics: Bile acid & Lithocholic acid. The author has an hindex of 11, co-authored 25 publications receiving 6283 citations. Previous affiliations of A. Sloan Devlin include University of California, San Francisco & California Institute for Quantitative Biosciences.
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Journal ArticleDOI
Diet rapidly and reproducibly alters the human gut microbiome
Lawrence A. David,Corinne F. Maurice,Rachel N. Carmody,David B. Gootenberg,Julie E. Button,Benjamin E. Wolfe,Alisha V. Ling,A. Sloan Devlin,Yug Varma,Michael A. Fischbach,Sudha B. Biddinger,Rachel J. Dutton,Peter J. Turnbaugh +12 more
TL;DR: Increases in the abundance and activity of Bilophila wadsworthia on the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorganisms capable of triggering inflammatory bowel disease.
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Bile acid metabolites control TH17 and Treg cell differentiation
Saiyu Hang,Donggi Paik,Lina Yao,Eunha Kim,Jamma Trinath,Jingping Lu,Soyoung Ha,Brandon N. Nelson,Samantha P. Kelly,Lin Wu,Ye Zheng,Randy S. Longman,Fraydoon Rastinejad,A. Sloan Devlin,Michael R. Krout,Michael A. Fischbach,Dan R. Littman,Dan R. Littman,Jun R. Huh,Jun R. Huh +19 more
TL;DR: Two derivatives of lithocholic acid are revealed that act as regulators of T helper cells that express IL-17a and regulatory T cells, thus influencing host immune responses.
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A biosynthetic pathway for a prominent class of microbiota-derived bile acids
TL;DR: It is shown, for the first time, that iso bile acids are produced by Ruminococcus gnavus, a far more abundant commensal than previously known producers; and that theiso bile acid pathway detoxifies deoxycholic acid, favoring the growth of the keystone genus Bacteroides.
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Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota
A. Sloan Devlin,Angela Marcobal,Dylan Dodd,Stephen Nayfach,Natalie S. Plummer,Timothy W. Meyer,Katherine S. Pollard,Justin L. Sonnenburg,Michael A. Fischbach +8 more
TL;DR: It is demonstrated that it is possible to control host IS levels by targeting the microbiota and suggest a possible strategy for treating renal disease.
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A selective gut bacterial bile salt hydrolase alters host metabolism
Lina Yao,Sarah Craven Seaton,Sula Ndousse-Fetter,Arijit A. Adhikari,Nicholas DiBenedetto,Amir I. Mina,Alexander S. Banks,Lynn Bry,A. Sloan Devlin +8 more
TL;DR: It is demonstrated that metabolites generated by a single microbial gene and enzymatic activity can profoundly alter host metabolism and gene expression at local and organism-level scales.