A
Adam Barker
Researcher at Medical Research Council
Publications - 4
Citations - 564
Adam Barker is an academic researcher from Medical Research Council. The author has contributed to research in topics: Type 2 diabetes & Diabetes mellitus. The author has an hindex of 4, co-authored 4 publications receiving 495 citations. Previous affiliations of Adam Barker include University of Newcastle.
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Journal ArticleDOI
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity
Antigone S. Dimas,Vasiliki Lagou,Adam Barker,Joshua W. Knowles,Reedik Mägi,Marie-France Hivert,Andrea Benazzo,Denis Rybin,Anne U. Jackson,Heather M. Stringham,Ci Song,Antje Fischer-Rosinsky,Trine Welløv Boesgaard,Niels Grarup,Fahim Abbasi,Themistocles L. Assimes,Ke Hao,Xia Yang,Cécile Lecoeur,Inês Barroso,Lori L. Bonnycastle,Yvonne Böttcher,Suzannah Bumpstead,Peter S. Chines,Michael R. Erdos,J. Graessler,Peter Kovacs,Mario A. Morken,Narisu Narisu,Felicity Payne,Alena Stančáková,Amy J. Swift,Anke Tönjes,Stefan R. Bornstein,Stéphane Cauchi,Philippe Froguel,David Meyre,Peter Schwarz,Hans-Ulrich Häring,Ulf Smith,Michael Boehnke,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Thomas Quertemous,Lars Lind,Torben Hansen,Oluf Pedersen,Mark Walker,Andreas Pfeiffer,Joachim Spranger,Michael Stumvoll,James B. Meigs,Nicholas J. Wareham,Johanna Kuusisto,Markku Laakso,Claudia Langenberg,Josée Dupuis,Richard M. Watanabe,Jose C. Florez,Erik Ingelsson,Mark I. McCarthy,Inga Prokopenko,Magic Investigators +64 more
TL;DR: By assembling extensive data on continuous glycemic traits, this work has exposed the diverse mechanisms whereby type 2 diabetes risk variants impact disease predisposition.
Journal ArticleDOI
Evidence of a causal association between insulinemia and endometrial cancer: a Mendelian randomization analysis
Kevin T. Nead,Stephen J. Sharp,Deborah J. Thompson,Jodie N. Painter,David B. Savage,Robert K. Semple,Adam Barker,John R. B. Perry,John Attia,Alison M. Dunning,Douglas F. Easton,Elizabeth G. Holliday,Luca A. Lotta,Tracy A. O'Mara,Mark McEvoy,Paul D.P. Pharoah,Rodney J. Scott,Amanda B. Spurdle,Claudia Langenberg,Nicholas J. Wareham,Robert A. Scott +20 more
TL;DR: Evidence is provided to support a causal association of higher insulin levels, independently of BMI, with endometrial cancer risk, as well as single nucleotide polymorphisms associated with T2D and body mass index as instrumental variables.
Journal ArticleDOI
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.
Adam Barker,Stephen J. Sharp,Nicholas J. Timpson,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Nicole M. Warrington,Stavroula Kanoni,Stavroula Kanoni,Lawrence J. Beilin,Soren Brage,Panos Deloukas,David M. Evans,Anders Grøntved,Neelam Hassanali,Debbie A Lawlor,Cécile Lecoeur,Cécile Lecoeur,Ruth J. F. Loos,Stephen J. Lye,Mark I. McCarthy,Mark I. McCarthy,Trevor A. Mori,Ndeye Coumba Ndiaye,John P. Newnham,Ioanna Ntalla,Craig E. Pennell,Beate St Pourcain,Inga Prokopenko,Inga Prokopenko,Susan M. Ring,Naveed Sattar,Sophie Visvikis-Siest,George Dedoussis,Lyle J. Palmer,Philippe Froguel,Philippe Froguel,Philippe Froguel,George Davey Smith,Ulf Ekelund,Nicholas J. Wareham,Claudia Langenberg +40 more
TL;DR: Novel fasting glucose loci identified in genome-wide association studies of adults are associated with altered fasting glucose levels in healthy children and adolescents with effect sizes comparable to adults, suggesting age-independent effects of these fasting glucose Loci contribute to long-term interindividual differences in glucose levels from childhood onwards.
Journal ArticleDOI
Genetic determinants of glucose homeostasis.
TL;DR: This review article focuses on describing the complex associations between type 1 diabetes risk variants and quantitative glycaemic traits and the relationship between variants initially discovered in association studies of these traits and risk of type 2 diabetes.