Malika Sud

TL;DR: An atlas of 366,650 cells from the colon mucosa of 18 UC patients and 12 healthy individuals is generated, revealing 51 epithelial, stromal, and immune cell subsets, including BEST4+ enterocytes, microfold-like cells, and IL13RA2+IL11+ inflammatory fibroblasts, which are associated with resistance to anti-TNF treatment.

TL;DR: In this article, single-cell analysis of lung, heart, kidney and liver autopsy samples shows the molecular and cellular changes and immune response resulting from severe SARS-CoV-2 infection.

TL;DR: In this article, the authors studied the cancer-immune interplay in synovial sarcoma using an integrative approach that combines single-cell RNA sequencing (scRNA-seq), spatial profiling and genetic and pharmacological perturbations.

TL;DR: In this paper, the authors used single-cell and single-nucleus RNA-Seq of lung, kidney, liver, and heart tissues collected during the clinical autopsy of 17 individuals who succumbed to the SARS-CoV-2 pandemic.

TL;DR: An atlas of 115,517 cells from the colon mucosa of seven UC patients and ten healthy individuals is generated, revealing 51 epithelial, stromal, and immune cell subsets, including a subset of BEST4+ enterocytes, which may sense and respond to pH, and IL13RA2+IL-11+ inflammatory fibroblasts, which the authors associate with resistance to anti-TNF therapy.