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Adam Wood
Researcher at Saint Louis University
Publications - 16
Citations - 3294
Adam Wood is an academic researcher from Saint Louis University. The author has contributed to research in topics: Histone code & Histone methylation. The author has an hindex of 13, co-authored 16 publications receiving 3114 citations. Previous affiliations of Adam Wood include Washington University in St. Louis & University of Toronto.
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Journal ArticleDOI
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
Nevan J. Krogan,Jim Dover,Adam Wood,Jessica Schneider,Jonathan Heidt,Marry Ann Boateng,Kimberly Dean,Owen Ryan,Ashkan Golshani,Mark Johnston,Jack Greenblatt,Ali Shilatifard +11 more
TL;DR: It is reported that the Paf1 protein complex, which is associated with the elongating RNA polymerase II, is required for methylation of lysines 4 and 79 of histone H3 and for silencing of expression of a telomere-associated gene.
Journal ArticleDOI
Methylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6
Jim Dover,Jessica Schneider,Mary Anne Tawiah-Boateng,Adam Wood,Kimberly Dean,Mark Johnston,Ali Shilatifard +6 more
TL;DR: The genome of the yeast Saccharomyces cerevisiae was surveyed for genes necessary for histone methylation, and it was discovered that the ubiquitin-conjugating enzyme Rad6 is required for methylation of lysine 4 of histone H3.
Journal ArticleDOI
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
Adam Wood,Nevan J. Krogan,Jim Dover,Jessica Schneider,Jonathan Heidt,Marry Ann Boateng,Kimberly Dean,Ashkan Golshani,Yi Zhang,Jack Greenblatt,Mark Johnston,Ali Shilatifard +11 more
TL;DR: In this paper, the authors identified Bre1 as the probable E3 for Rad6's role in transcription and showed that Bre1 is the likely E3 enzyme that directs Rad6 to modify chromatin and ultimately to affect gene expression.
Journal ArticleDOI
The Paf1 Complex Is Essential for Histone Monoubiquitination by the Rad6-Bre1 Complex, Which Signals for Histone Methylation by COMPASS and Dot1p
TL;DR: In addition to its role during the elongation phase of transcription, the Paf1 complex appears to activate the function but not the placement of the Rad6-Bre1 ubiquitin-protein ligase at the promoters of active genes.
Journal ArticleDOI
Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression.
Jessica Schneider,Adam Wood,Jung Shin Lee,Rebecca Schuster,Jeff Dueker,Courtney Maguire,Selene K. Swanson,Laurence Florens,Michael P. Washburn,Ali Shilatifard +9 more
TL;DR: A comparative global proteomic screen suggests a molecular requirement for several components of COMPASS for proper histone H3 trimethylation and regulation of telomere-associated gene expression, indicating multiple roles for different forms of histone methylation by COMPASS.