A
Adrian B. Hehl
Researcher at University of Zurich
Publications - 99
Citations - 5372
Adrian B. Hehl is an academic researcher from University of Zurich. The author has contributed to research in topics: Giardia lamblia & Golgi apparatus. The author has an hindex of 39, co-authored 92 publications receiving 4841 citations. Previous affiliations of Adrian B. Hehl include Fairchild Semiconductor International, Inc. & Stanford University.
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Journal ArticleDOI
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia.
Hilary G. Morrison,Andrew G. McArthur,Frances D. Gillin,Stephen B. Aley,Rodney D. Adam,Gary J. Olsen,Aaron A. Best,W. Zacheus Cande,Feng Chen,Michael J. Cipriano,Barbara J. Davids,Scott C. Dawson,Heidi G. Elmendorf,Adrian B. Hehl,Michael Holder,Susan M. Huse,Ulandt Kim,Erica Lasek-Nesselquist,Gerard Manning,Anuranjini Nigam,Julie E. J. Nixon,Daniel Palm,Nora Q.E. Passamaneck,Anjali Prabhu,Claudia I. Reich,David S. Reiner,John Samuelson,Staffan G. Svärd,Mitchell L. Sogin +28 more
TL;DR: The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways.
Journal ArticleDOI
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries.
Michael E. Grigg,Serge Bonnefoy,Adrian B. Hehl,Yasuhiro Suzuki,Yasuhiro Suzuki,John C. Boothroyd +5 more
TL;DR: Sexual recombination, by combining polymorphisms in two distinct and competing clonal lines, can be a powerful force driving the natural evolution of virulence in this highly successful pathogen.
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Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa.
James W. Ajioka,John C. Boothroyd,Brian P. Brunk,Adrian B. Hehl,Ledeana Hillier,Ian D. Manger,Marco A. Marra,G. Christian Overton,David S. Roos,Kiew Lian Wan,Robert H. Waterston,L. David Sibley +11 more
TL;DR: To accelerate gene discovery and facilitate genetic mapping in the protozoan parasite Toxoplasma gondii, >7000 new ESTs from the 5' ends of randomly selected tachyzoite cDNAs are generated, with success in identifying new genes.
Journal ArticleDOI
Toxoplasma gondii homologue of Plasmodium apical membrane antigen 1 is involved in invasion of host cells.
Adrian B. Hehl,Adrian B. Hehl,Christine Lekutis,Michael E. Grigg,Peter J. Bradley,Jean-François Dubremetz,Eduardo Ortega-Barria,John C. Boothroyd +7 more
TL;DR: The identification and characterization of TgAMA1, the Toxoplasma gondii homolog of the Plasmodium apical membrane antigen 1 (AMA1), which has been shown to elicit a protective immune response against merozoites dependent on the correct pairing of its numerous disulfide bonds is described.
Journal ArticleDOI
Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells.
Emma Ringqvist,J. E. Daniel Palm,J. E. Daniel Palm,Hanna Skarin,Adrian B. Hehl,Malin E.-L. Weiland,Barbara J. Davids,David S. Reiner,David S. Reiner,William J. Griffiths,Lars Eckmann,Frances D. Gillin,Staffan G. Svärd,Staffan G. Svärd +13 more
TL;DR: Results indicate that contact of Giardia with epithelial cells triggers metabolic enzyme release, which might facilitate effective colonization of the human small intestine.