Journal ArticleDOI
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia.
Hilary G. Morrison,Andrew G. McArthur,Frances D. Gillin,Stephen B. Aley,Rodney D. Adam,Gary J. Olsen,Aaron A. Best,W. Zacheus Cande,Feng Chen,Michael J. Cipriano,Barbara J. Davids,Scott C. Dawson,Heidi G. Elmendorf,Adrian B. Hehl,Michael Holder,Susan M. Huse,Ulandt Kim,Erica Lasek-Nesselquist,Gerard Manning,Anuranjini Nigam,Julie E. J. Nixon,Daniel Palm,Nora Q.E. Passamaneck,Anjali Prabhu,Claudia I. Reich,David S. Reiner,John Samuelson,Staffan G. Svärd,Mitchell L. Sogin +28 more
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TLDR
The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways.Abstract:
The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways. Protein kinases comprise the single largest protein class and reflect Giardia's requirement for a complex signal transduction network for coordinating differentiation. Lateral gene transfer from bacterial and archaeal donors has shaped Giardia's genome, and previously unknown gene families, for example, cysteine-rich structural proteins, have been discovered. Unexpectedly, the genome shows little evidence of heterozygosity, supporting recent speculations that this organism is sexual. This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite.read more
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Journal ArticleDOI
Actin, a Central Player in Cell Shape and Movement
Thomas D. Pollard,John A. Cooper +1 more
TL;DR: Comparisons of quantitative measurements of reactions in live cells with computer simulations of mathematical models will help generate meaningful insights and present a summary of the key questions in the field.
Journal ArticleDOI
Horizontal gene transfer in eukaryotic evolution
TL;DR: The number of well-supported cases of transfer from both prokaryotes and eukaryotes, many with significant functional implications, is now expanding rapidly and major recent trends include the important role of HGT in adaptation to certain specialized niches and the highly variable impact of H GT in different lineages.
Journal ArticleDOI
Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes
Miklós Müller,Marek Mentel,Jaap J. van Hellemond,Katrin Henze,Christian Woehle,Sven B. Gould,Re-Young Yu,Mark van der Giezen,Aloysius G.M. Tielens,William Martin +9 more
TL;DR: The gene distribution across lineages reflects the presence of anaerobic energy metabolism in the eukaryote common ancestor and differential loss during the specialization of some lineages to oxic niches, just as oxphos capabilities have been differentially lost in specialization to anoxic niches and the parasitic life-style.
Journal ArticleDOI
Zoonotic potential of Giardia.
Una Ryan,Simone M. Cacciò +1 more
TL;DR: A better understanding of the genetics of this parasite is required to allow the design of more sensitive and variable subtyping tools, that in turn may help unravel the complex epidemiology of this infection.
Journal ArticleDOI
Molecular epidemiology of giardiasis
Simone M. Cacciò,Una Ryan +1 more
TL;DR: A coherent picture has emerged from studies, indicating the existence of seven genetic groups (or assemblages), two of which are found in both humans and animals, whereas the remaining five (C-G) are host-specific.
References
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Journal ArticleDOI
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
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An evolving view of the eukaryotic oligosaccharyltransferase
Daniel J. Kelleher,Reid Gilmore +1 more
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Journal ArticleDOI
A Phylogenomic Inventory of Meiotic Genes: Evidence for Sex in Giardia and an Early Eukaryotic Origin of Meiosis
TL;DR: The presence of five meiosis-specific genes indicates that Giardia is capable of meiotic and, thus, sexual reproduction, and the evolution of meiosis occurred early in eukaryotic evolution.
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