W
W. Zacheus Cande
Researcher at University of California, Berkeley
Publications - 88
Citations - 9686
W. Zacheus Cande is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Meiosis & Mitosis. The author has an hindex of 49, co-authored 88 publications receiving 9007 citations. Previous affiliations of W. Zacheus Cande include University of California, Davis & University of California, San Francisco.
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Journal ArticleDOI
Three-Dimensional Resolution Doubling in Wide-Field Fluorescence Microscopy by Structured Illumination
Mats G. L. Gustafsson,Lin Shao,Peter M. Carlton,C. J. Rachel Wang,Inna N. Golubovskaya,W. Zacheus Cande,David A. Agard,David A. Agard,John W. Sedat +8 more
TL;DR: This work describes how spatially structured illumination microscopy can be applied in three dimensions to double the axial as well as the lateral resolution, with true optical sectioning, and has produced the first light microscopy images of the synaptonemal complex in which the lateral elements are clearly resolved.
Journal ArticleDOI
Structural basis for double-stranded RNA processing by Dicer.
Ian J. MacRae,Kaihong Zhou,Fei Li,Adrian Repic,Angela N. Brooks,W. Zacheus Cande,Paul D. Adams,Jennifer A. Doudna +7 more
TL;DR: In the crystal structure of an intact Dicer enzyme, the PAZ domain, a module that binds the end of dsRNA, is separated from the two catalytic ribonuclease III (RNase III) domains by a flat, positively charged surface.
Journal ArticleDOI
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia.
Hilary G. Morrison,Andrew G. McArthur,Frances D. Gillin,Stephen B. Aley,Rodney D. Adam,Gary J. Olsen,Aaron A. Best,W. Zacheus Cande,Feng Chen,Michael J. Cipriano,Barbara J. Davids,Scott C. Dawson,Heidi G. Elmendorf,Adrian B. Hehl,Michael Holder,Susan M. Huse,Ulandt Kim,Erica Lasek-Nesselquist,Gerard Manning,Anuranjini Nigam,Julie E. J. Nixon,Daniel Palm,Nora Q.E. Passamaneck,Anjali Prabhu,Claudia I. Reich,David S. Reiner,John Samuelson,Staffan G. Svärd,Mitchell L. Sogin +28 more
TL;DR: The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways.
Journal ArticleDOI
The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility
Lillian K. Fritz-Laylin,Simon E. Prochnik,Michael L. Ginger,Joel B. Dacks,Joel B. Dacks,Meredith L. Carpenter,Mark C. Field,Alan Kuo,Alexander R. Paredez,Jarrod Chapman,Jonathan K Pham,Shengqiang Shu,Rochak Neupane,Michael J. Cipriano,Joel Mancuso,Hank Tu,Asaf Salamov,Erika Lindquist,Harris Shapiro,Susan Lucas,Igor V. Grigoriev,W. Zacheus Cande,Chandler Fulton,Daniel S. Rokhsar,Daniel S. Rokhsar,Scott C. Dawson +25 more
TL;DR: The Naegleria genome facilitates substantially broader phylogenomic comparisons of free-living eukaryotes than previously possible, allowing us to identify thousands of genes likely present in the pan-eukaryotic ancestor, with 40% likely eukARYotic inventions.
Journal ArticleDOI
A unified phylogeny-based nomenclature for histone variants
Paul B. Talbert,Kami Ahmad,Geneviève Almouzni,Juan Ausió,Frédéric Berger,Prem L. Bhalla,William M. Bonner,W. Zacheus Cande,Brian P. Chadwick,Simon W. L. Chan,George A. M. Cross,Liwang Cui,Stefan Dimitrov,Detlef Doenecke,José M. Eirín-López,Martin A. Gorovsky,Sandra B. Hake,Barbara A. Hamkalo,Sarah Holec,Steven E. Jacobsen,Kinga Kamieniarz,Saadi Khochbin,Andreas G. Ladurner,David Landsman,John A Latham,Benjamin Loppin,Harmit S. Malik,William F. Marzluff,John R. Pehrson,Jan Postberg,Robert Schneider,Mohan Singh,M. Mitchel Smith,Eric M. Thompson,Maria-Elena Torres-Padilla,David J. Tremethick,Bryan M. Turner,Jakob H. Waterborg,Heike Wollmann,Ramesh Yelagandula,Bing Zhu,Steven Henikoff +41 more
TL;DR: A unified nomenclature for variants of all five classes of histones is proposed that uses consistent but flexible naming conventions to produce names that are informative and readily searchable and incorporates phylogenetic relationships, which are strong predictors of structure and function.