J
John Samuelson
Researcher at Boston University
Publications - 119
Citations - 6992
John Samuelson is an academic researcher from Boston University. The author has contributed to research in topics: Entamoeba histolytica & Gene. The author has an hindex of 44, co-authored 118 publications receiving 6695 citations. Previous affiliations of John Samuelson include Max Planck Society & Brigham and Women's Hospital.
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Journal ArticleDOI
The genome of the protist parasite Entamoeba histolytica
Brendan J. Loftus,Iain J. Anderson,Robert L. Davies,U. Cecilia M. Alsmark,John Samuelson,Paolo Amedeo,Paola Roncaglia,Matthew Berriman,Robert P. Hirt,Barbara J. Mann,Tomo Nozaki,Bernard B. Suh,Mihai Pop,Michael Duchêne,John P. Ackers,Egbert Tannich,Matthias Leippe,Margit Hofer,Iris Bruchhaus,Ute Willhoeft,Alok Bhattacharya,Tracey Chillingworth,Carol Churcher,Zahra Hance,Barbara Harris,David Harris,Kay Jagels,Sharon Moule,Karen Mungall,Doug Ormond,Rob Squares,Sally Whitehead,Michael A. Quail,Ester Rabbinowitsch,Halina Norbertczak,Claire Price,Zheng Wang,Nancy Guillén,Carol A. Gilchrist,Suzanne Stroup,Sudha Bhattacharya,Anuradha Lohia,Peter G. Foster,Thomas Sicheritz-Pontén,Christian Weber,Upinder Singh,Chandrama Mukherjee,Najib M. El-Sayed,William A. Petri,C. Graham Clark,T. Martin Embley,Bart Barrell,Claire M. Fraser,Neil Hall,Neil Hall +54 more
TL;DR: The genome of E. histolytica is presented, which reveals a variety of metabolic adaptations shared with two other amitochondrial protist pathogens: Giardia lamblia and Trichomonas vaginalis, and provides new insights into the workings and genome evolution of a major human pathogen.
Journal ArticleDOI
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia.
Hilary G. Morrison,Andrew G. McArthur,Frances D. Gillin,Stephen B. Aley,Rodney D. Adam,Gary J. Olsen,Aaron A. Best,W. Zacheus Cande,Feng Chen,Michael J. Cipriano,Barbara J. Davids,Scott C. Dawson,Heidi G. Elmendorf,Adrian B. Hehl,Michael Holder,Susan M. Huse,Ulandt Kim,Erica Lasek-Nesselquist,Gerard Manning,Anuranjini Nigam,Julie E. J. Nixon,Daniel Palm,Nora Q.E. Passamaneck,Anjali Prabhu,Claudia I. Reich,David S. Reiner,John Samuelson,Staffan G. Svärd,Mitchell L. Sogin +28 more
TL;DR: The genome of the eukaryotic protist Giardia lamblia, an important human intestinal parasite, is compact in structure and content, contains few introns or mitochondrial relics, and has simplified machinery for DNA replication, transcription, RNA processing, and most metabolic pathways.
Journal ArticleDOI
The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases
John Samuelson,Sulagna Banerjee,Paula Magnelli,Jike Cui,Daniel J. Kelleher,Reid Gilmore,Phillips W. Robbins +6 more
TL;DR: It is demonstrated that common ancestry is a useful method of predicting the Alg glycosyltransferase inventory of each eukaryote, and in the vast majority of cases, this inventory accurately predicts the dolichol-PP-glycans observed.
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Why Metronidazole Is Active against both Bacteria and Parasites
TL;DR: Metronidazole is one of the rare examples of a drug developed against a parasite which has since gained broad use as an antibacterial agent and was screened for activity against Trichomonas vaginalis.
Journal ArticleDOI
Hsp60 Is Targeted to a Cryptic Mitochondrion-Derived Organelle ("Crypton") in the Microaerophilic Protozoan Parasite Entamoeba Histolytica
TL;DR: It is suggested that the Hsp60-associated, mitochondrion-derived organelle identified here be named “crypton,” as its structure was previously hidden and its function is still cryptic.