A
Adriana Bolasco
Researcher at Sapienza University of Rome
Publications - 96
Citations - 3997
Adriana Bolasco is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Monoamine oxidase & Docking (molecular). The author has an hindex of 39, co-authored 96 publications receiving 3657 citations. Previous affiliations of Adriana Bolasco include University of Cagliari.
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Synthesis and cytotoxicity of novel (thiazol-2-yl)hydrazine derivatives as promising anti-Candida agents.
Simone Carradori,Daniela Secci,Adriana Bolasco,Daniela Rivanera,Emanuela Mari,Alessandra Zicari,Lavinia Vittoria Lotti,Bruna Bizzarri +7 more
TL;DR: The concurrent presence of aliphatic chains or cycloaliphatic rings at N1-hydrazine and a 4-methyl/4-methoxyphenyl at C4 position of the thiazole nucleus exhibited an interesting anti-Candida inhibitory activity.
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Synthesis and biological evaluation of novel conjugated coumarin‐thiazole systems
Franco Chimenti,Simone Carradori,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Bruna Bizzarri +6 more
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Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors.
Daniela Secci,Simone Carradori,Adriana Bolasco,Bruna Bizzarri,Melissa D'Ascenzio,Elias Maccioni +5 more
TL;DR: Pyrazolines could be considered a valid pharmacophore for the synthesis of selective monoamine oxidase (MAO) inhibitors because they were developed by the cyclization of the early hydrazine derivatives such as isocarboxazid.
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Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.
Daniela Secci,Adriana Bolasco,Simone Carradori,Melissa D'Ascenzio,Riccardo Nescatelli,Matilde Yáñez +5 more
TL;DR: A large series of (4-substituted-thiazol-2-yl)hydrazine derivatives was synthesized in good yield and assayed for their in vitro human monoamine oxidase (hMAO) inhibitory activity and selectivity, demonstrating interest in this privileged scaffold.
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Synthesis Stereochemical Separation and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines
Franco Chimenti,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Simone Carradori,Matilde Yáñez,Francisco Orallo,M. Luisa Sanna,Bruno Gallinella,Roberto Cirilli +10 more
TL;DR: Novel 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine derivatives have been investigated for their ability to inhibit selectively the activity of the human B isoform of monoamine oxidase.