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Adriana Bolasco
Researcher at Sapienza University of Rome
Publications - 96
Citations - 3997
Adriana Bolasco is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Monoamine oxidase & Docking (molecular). The author has an hindex of 39, co-authored 96 publications receiving 3657 citations. Previous affiliations of Adriana Bolasco include University of Cagliari.
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Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.
Franco Chimenti,Bruna Bizzarri,Elias Maccioni,Daniela Secci,Adriana Bolasco,Rossella Fioravanti,Paola Chimenti,Arianna Granese,Simone Carradori,Daniela Rivanera,D. Lilli,Alessandra Zicari,Simona Distinto +12 more
TL;DR: A novel series of 2-thiazolylhydrazone derivatives and the influence of the substituents on the thiazole ring on antifungal activity is reported and in general they were shown to induce low cytotoxic effects.
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Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives.
Franco Chimenti,Elias Maccioni,Daniela Secci,Adriana Bolasco,Paola Chimenti,Arianna Granese,Olivia Befani,Paola Turini,Stefano Alcaro,Francesco Ortuso,Maria Cristina Cardia,Simona Distinto +11 more
TL;DR: A series of 2-thiazolylhydrazone derivatives have been investigated for the ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) selectively and all of the compounds showed high activity against both the MAO-A and theMAO-B isoforms.
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Focusing on new monoamine oxidase inhibitors
TL;DR: This review highlights the recent MAO inhibitors related patents published from July 2005 to December 2009 and reports on new associations of already known MAO inhibitor with other drugs, innovative therapeutic targets,MAO inhibitors obtained by plants extraction, alternative administration routes and synthetic processes.
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Monoamine Oxidase Isoform-Dependent Tautomeric Influence in the Recognition of 3,5-Diaryl Pyrazole Inhibitors
Franco Chimenti,Rossella Fioravanti,Adriana Bolasco,Fedele Manna,Paola Chimenti,Daniela Secci,Olivia Befani,Paola Turini,Francesco Ortuso,Stefano Alcaro +9 more
TL;DR: A series of 3,5-diaryl pyrazoles were prepared and assayed for their ability to inhibit reversibly monoamine oxidase-A (MAO-A) and monoamines oxidase B (MaO-B) and several compounds show inhibitory activity with concentration values in the nanomolar range.
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Anti-inflammatory, analgesic and antipyretic 4,6-disubstituted 3-cyanopyridine-2-ones and 3-cyano-2-aminopyridines
Fedele Manna,Franco Chimenti,Adriana Bolasco,Amelia Filippelli,A. Palla,Walter Filippelli,E. Lampa,R. Mercantini +7 more
TL;DR: In this paper, 3-Cyano-4-(R,R′-aryl)-6(2-hydroxyphenyl)-2-(1H)pyridones 2a, 2d, 2i, 2m and 2o were synthesized which showed anti-inflammatory and analgesic activity.