A
Adriana Bolasco
Researcher at Sapienza University of Rome
Publications - 96
Citations - 3997
Adriana Bolasco is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Monoamine oxidase & Docking (molecular). The author has an hindex of 39, co-authored 96 publications receiving 3657 citations. Previous affiliations of Adriana Bolasco include University of Cagliari.
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Journal ArticleDOI
Anti-inflammatory, analgesic and antipyretic N-acetyl-Δ2-pyrazolines and dihydrothienocoumarines
Fedele Manna,Franco Chimenti,Adriana Bolasco,ML Cenicola,Michele D'Amico,C Parrillo,Francesca Rossi,E. Marmo +7 more
TL;DR: In this article, the substituents on the 5-aryl group were necessary for biological activity and showed anti-inflammatory and analgesic activity in N-acetyl-Δ2-pyrazoline and dihydrothienocoumarines.
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Analytical and semipreparative high performance liquid chromatography enantioseparation of new substituted 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazoles on polysaccharide-based chiral stationary phases in normal-phase, polar organic and reversed-phase conditions.
Roberto Cirilli,A Simonelli,Rosella Ferretti,Adriana Bolasco,Paola Chimenti,Daniela Secci,Elias Maccioni,F. La Torre +7 more
TL;DR: Chiralpak IA exhibited an excellent chiral resolving ability in normal-phase mode and it allowed the enantioseparation of analytes investigated with resolution factors >20, and was successfully employed at analytical and semipreparative scale in combination with normal- phase eluents containing "non-standards" solvents such as acetone.
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Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives.
Franco Chimenti,Bruna Bizzarri,Fedele Manna,Adriana Bolasco,Daniela Secci,Paola Chimenti,Arianna Granese,Daniela Rivanera,D. Lilli,M.M. Scaltrito,Brenciaglia Mi +10 more
TL;DR: Among the prepared compounds those with an N1-acetyl group and a 4-methoxy substituent in the 5-phenyl ring showed the best activity against H. pylori metronidazole resistant strains in the 1-4 microg/mL MIC range.
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Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors.
Daniela Secci,Simone Carradori,Bruna Bizzarri,Adriana Bolasco,Paola Ballario,Zoi Patramani,Paola Fragapane,Stefano Vernarecci,Claudia Canzonetta,Patrizia Filetici +9 more
TL;DR: The results show the efficacy of this novel HAT inhibitor and propose the utilization of BF1 as a new, promising tool for future pharmacological studies.
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Synthesis, biological evaluation and 3D-QSAR of 1,3,5-trisubstituted-4,5-dihydro-(1H)-pyrazole derivatives as potent and highly selective monoamine oxidase A inhibitors.
Franco Chimenti,Adriana Bolasco,Fedele Manna,Daniela Secci,Paola Chimenti,Arianna Granese,Olivia Befani,Paola Turini,Roberto Cirilli,Francesco La Torre,Stefano Alcaro,Francesco Ortuso,Thierry Langer +12 more
TL;DR: A extended study of the chemistry, the inhibitory activity against monoamino oxidases (MAO), and molecular modeling including the 3D-QSAR hypothesis of 1,3,5-trisubstituted-4, 5-dihydro-(1H)-pyrazole derivatives to derive a suitable selectivity model is provided.