S
Shabir Lakhi
Researcher at University of Zambia
Publications - 70
Citations - 2843
Shabir Lakhi is an academic researcher from University of Zambia. The author has contributed to research in topics: Viral load & Population. The author has an hindex of 24, co-authored 67 publications receiving 2398 citations. Previous affiliations of Shabir Lakhi include Emory University & International AIDS Vaccine Initiative.
Papers
More filters
Journal ArticleDOI
Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial.
Ben Andrews,Ben Andrews,Matthew W. Semler,Levy Muchemwa,Paul Kelly,Paul Kelly,Shabir Lakhi,Douglas C. Heimburger,Chileshe Mabula,Mwango Bwalya,Gordon R. Bernard +10 more
TL;DR: A protocol for early resuscitation with administration of intravenous fluids and vasopressors increased in-hospital mortality compared with usual care among adults with sepsis and hypotension in Zambian adults presenting to the emergency department at a 1500-bed referral hospital.
Journal ArticleDOI
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa
Síle F. Molloy,Cecilia Kanyama,Robert S. Heyderman,Angela Loyse,Charles Kouanfack,Duncan Chanda,Sayoki Mfinanga,Elvis Temfack,Shabir Lakhi,Sokoine Lesikari,Adrienne K. Chan,Neil Stone,Newton Kalata,Natasha Karunaharan,Katherine M Gaskell,Mary Peirse,Jayne Ellis,Chimwemwe Chawinga,Sandrine Lontsi,Jean-Gilbert Ndong,Philip Bright,Duncan Lupiya,Tao Chen,John S. Bradley,Jack Adams,Charles van der Horst,Joep J. van Oosterhout,Victor Sini,Yacouba Mapoure,Peter Mwaba,Tihana Bicanic,David G. Lalloo,Duolao Wang,Mina C. Hosseinipour,Olivier Lortholary,Shabbar Jaffar,Tom Harrison +36 more
TL;DR: Two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy were tested.
Journal ArticleDOI
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
Elise Landais,Xiayu Huang,Colin Havenar-Daughton,Colin Havenar-Daughton,Ben Murrell,Matthew Price,Matthew Price,Lalinda Wickramasinghe,Alejandra Ramos,Charoan B. Bian,Melissa Simek,Susan Allen,Etienne Karita,William Kilembe,Shabir Lakhi,Mubiana Inambao,Anatoli Kamali,Eduard J. Sanders,Eduard J. Sanders,Omu Anzala,Vinodh A. Edward,Linda-Gail Bekker,Jianming Tang,Jill Gilmour,Sergei L. Kosakovsky-Pond,Pham Phung,Terri Wrin,Shane Crotty,Shane Crotty,Adam Godzik,Pascal Poignard,Pascal Poignard +31 more
TL;DR: Cross-clade neutralization strongly correlated with high viral load as well as with low CD4 T cell counts, subtype-C infection and HLA-A*03(-) genotype, suggesting the HIV Env N332-glycan supersite may be a favorable target for vaccine design.
Journal ArticleDOI
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients
Hayley Crawford,Wendy Lumm,Alasdair Leslie,Malinda Schaefer,Debrah I. Boeras,Julia G. Prado,Jianming Tang,Paul K. Farmer,Thumbi Ndung'u,Thumbi Ndung'u,Shabir Lakhi,Jill Gilmour,Paul A. Goepfert,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Richard A. Kaslow,Joseph Mulenga,Susan Allen,Susan Allen,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Eric Hunter,Eric Hunter +24 more
TL;DR: In vivo data demonstrate that, although costly escape from CTL responses can progressively attenuate the virus, high viral loads develop in the absence of adequate, continued CTL response, underline the need for a CTL vaccine against multiple conserved epitopes.
Journal ArticleDOI
Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort
Elise Landais,Xiayu Huang,Colin Havenar-Daughton,Ben Murrell,Matthew Price,Lalinda Wickramasinghe,Alejandra Ramos,Charoan B. Bian,Melissa Simek,Susan Allen,Etienne Karita,William Kilembe,Shabir Lakhi,Mubiana Inambao,Anatoli Kamali,Eduard J. Sanders,Omu Anzala,Vinodh A. Edward,Linda-Gail Bekker,Jianming Tang,Jill Gilmour,Sergei L. Kosakovsky-Pond,Pham Phung,Terri Wrin,Shane Crotty,Adam Godzik,Pascal Poignard +26 more
TL;DR: In this article, a large longitudinal cohort of primary HIV-1 infection in Eastern and South Africa was evaluated in 439 donors using a 6 cross-clade pseudo-virus panel predictive of neutralization breadth on larger panels.