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AH Stam
Researcher at Leiden University Medical Center
Publications - 14
Citations - 1258
AH Stam is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Familial hemiplegic migraine & Migraine. The author has an hindex of 14, co-authored 14 publications receiving 1110 citations.
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Journal ArticleDOI
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Anttila,Hreinn Stefansson,Mikko Kallela,U. Todt,Gisela M. Terwindt,Calafato Ms,Dale R. Nyholt,Antigone S. Dimas,T. Freilinger,Bertram Müller-Myhsok,Artto,Michael Inouye,Kirsi Alakurtti,Mari A. Kaunisto,Eija Hämäläinen,de Vries B,AH Stam,Claudia M Weller,Axel Heinze,Katja Heinze-Kuhn,Ingrid Goebel,Guntram Borck,H. Gobel,Stacy Steinberg,Christiane Wolf,Asgeir Björnsson,Gudmundur H. Gudmundsson,M. Kirchmann,A. Hauge,Thomas Werge,Jean Schoenen,Johan G. Eriksson,Knut Hagen,Lars Jacob Stovner,Heinz Erich Wichmann,Thomas Meitinger,Michael Alexander,Susanne Moebus,Stefan Schreiber,Yurii S. Aulchenko,Monique M.B. Breteler,André G. Uitterlinden,Albert Hofman,van Duijn Cm,P. Tikka-Kleemola,S. Vepsalainen,Susanne Lucae,Federica Tozzi,Pierandrea Muglia,Jeffrey C. Barrett,Jaakko Kaprio,Markus Färkkilä,Leena Peltonen,K. Stefansson,John-Anker Zwart,Ferrari,Jes Olesen,Mark J. Daly,Maija Wessman,van den Maagdenberg Am,Martin Dichgans,Christian Kubisch,Emmanouil T. Dermitzakis,Rune R. Frants,Aarno Palotie +64 more
TL;DR: This article identified the minor allele of rs1835740 on chromosome 8q22.1 to be associated with migraine (P = 5.38 x 10(-)(9), odds ratio = 1.23, 95% CI 1.150-1.324) in a genomewide association study of 2,731 migraine cases ascertained from three European headache clinics and 10,747 population-matched controls.
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Verneri Anttila,Hreinn Stefansson,Mikko Kallela,U. Todt,Gisela M. Terwindt,Maria S Calafato,Dale R. Nyholt,Antigone S. Dimas,T. Freilinger,Bertram Müller-Myhsok,Ville Artto,Michael Inouye,Kirsi Alakurtti,Mari A. Kaunisto,Eija Hämäläinen,B. B. A. De Vries,AH Stam,Claudia M Weller,Axel Heinze,Katja Heinze-Kuhn,Ingrid Goebel,Guntram Borck,H. Gobel,Stacy Steinberg,Christiane Wolf,Asgeir Björnsson,Gudmundur H. Gudmundsson,M. Kirchmann,A. Hauge,Thomas Werge,Jean Schoenen,Johan G. Eriksson,Knut Hagen,Lars Jacob Stovner,Heinz Erich Wichmann,Thomas Meitinger,M. Alexander,Susanne Moebus,Stefan Schreiber,Y S Aulchenko,Monique M.B. Breteler,André G. Uitterlinden,Albert Hofman,C M van Duijn,P. Tikka-Kleemola,Salli Vepsäläinen,Susanne Lucae,Federica Tozzi,Pierandrea Muglia,Jeffrey C. Barrett,Jaakko Kaprio,Markus Färkkilä,Leena Peltonen,K. Stefansson,John-Anker Zwart,Michel D. Ferrari,Jes Olesen,Mark J. Daly,Maija Wessman,A.M.J.M. van den Maagdenberg,Martin Dichgans,Christian Kubisch,Emmanouil T. Dermitzakis,R.R. Frants,Aarno Palotie +64 more
TL;DR: To the knowledge, the data establish rs1835740 as the first genetic risk factor for migraine.
Journal ArticleDOI
Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine
B. B. A. de Vries,T. Freilinger,K R J Vanmolkot,Jan B. Koenderink,AH Stam,G.M. Terwindt,Elena Babini,E. H. van den Boogerd,J. J. M. W. van den Heuvel,Rune R. Frants,Joost Haan,Michael Pusch,A.M.J.M. van den Maagdenberg,M. D. Ferrari,Martin Dichgans +14 more
TL;DR: The findings reinforce the hypothesis that FHM, SHM, and “normal” migraine are part of a disease spectrum with shared pathogenetic mechanisms.
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Padhraig Gormley,Verneri Anttila,Bendik S. Winsvold,Priit Palta,Tõnu Esko,Tune H. Pers,K.-H. Farh,E. Cuenca-Leon,Mikko Muona,N.A. Furlotte,Tobias Kurth,Andres Ingason,Gearoid M. McMahon,Lannie Ligthart,Gisela M. Terwindt,Mikko Kallela,T. Freilinger,Caroline Ran,G. Gordon,AH Stam,Stacy Steinberg,Guntram Borck,Markku Koiranen,Lydia Quaye,Hieab H.H. Adams,Terho Lehtimäki,Antti-Pekka Sarin,Juho Wedenoja,David A. Hinds,Julie E. Buring,Markus Schürks,Paul M. Ridker,M.G. Hrafnsdottir,Hreinn Stefansson,S.M. Ring,Jouke-Jan Hottenga,Brenda W.J.H. Penninx,Markus Färkkilä,Ville Artto,Mari A. Kaunisto,Salli Vepsäläinen,Rainer Malik,A. C. Heath,P. A. F. Madden,Glynn Martin,Grant W. Montgomery,Eija Hämäläinen,Hailiang Huang,Andrea Byrnes,Lude Franke,Jie Huang,Evie Stergiakouli,Phil Lee,Cynthia Sandor,Caleb Webber,Zameel Cader,Bertram Müller-Myhsok,Stefan Schreiber,Thomas Meitinger,Johan G. Eriksson,V. Salomaa,Kauko Heikkilä,Elizabeth Loehrer,André G. Uitterlinden,Albert Hofman,C M van Duijn,Lynn Cherkas,Linda M. Pedersen,Audun Stubhaug,Christopher Sivert Nielsen,Minna Männikkö,Evelin Mihailov,Lili Milani,H. Gobel,A.-L. Esserlind,Annette Christensen,Thomas Hansen,Thomas Werge,Jaakko Kaprio,Arpo Aromaa,Olli T. Raitakari,Ikram,Tim D. Spector,Marjo-Riitta Järvelin,Andres Metspalu,Christian Kubisch,David P. Strachan,Ferrari,Andrea Carmine Belin,Martin Dichgans,Maija Wessman,A.M.J.M. van den Maagdenberg,John-Anker Zwart,Dorret I. Boomsma,George Davey Smith,K. Stefansson,Nicholas Eriksson,Mark J. Daly,Benjamin M. Neale,Jes Olesen,Daniel I. Chasman,Dale R. Nyholt,Aarno Palotie,Lyn R. Griffiths,Huiying Zhao +104 more
TL;DR: For example, the authors identified 45 independent single nucleotide polymorphisms (SNPs) significantly associated with migraine risk that map to 38 distinct genomic loci, including 28 loci not previously reported and the first locus identified on chromosome X.
Journal ArticleDOI
First Mutation in the Voltage-Gated Nav1.1 Subunit Gene SCN1A with Co-Occurring Familial Hemiplegic Migraine and Epilepsy
M-J Castro,AH Stam,Carolina Lemos,B. B. A. de Vries,K R J Vanmolkot,João Paulo Pereira Barros,G.M. Terwindt,Rune R. Frants,Jorge Sequeiros,Ferrari,José Pereira-Monteiro,Amjm van den Maagdenberg +11 more
TL;DR: The L263V mutation is the first SCN1A mutation associated with FHM and co-occurring epilepsy in multiple mutation carriers, and is the clearest molecular link between migraine and epilepsy thus far.