J
Jitka Stancikova
Researcher at Academy of Sciences of the Czech Republic
Publications - 7
Citations - 630
Jitka Stancikova is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Wnt signaling pathway & Stem cell. The author has an hindex of 6, co-authored 7 publications receiving 506 citations.
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Journal ArticleDOI
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Zeli Shen,James G. Fox,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang +30 more
TL;DR: It is shown that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus, providing targets within the neoplastic gastric stem cell niche.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang,Zeli Shen,James G. Fox +29 more
TL;DR: In this article, the authors proposed a new method for cancer drug discovery based on protein-protein interactions, and obtained grants from the National Institutes of Health (U.S.) (Grants 54CA126513, R01CA093405, R1CA120979, and R1DK052778).
Journal ArticleDOI
Troy, a Tumor Necrosis Factor Receptor Family Member, Interacts With Lgr5 to Inhibit Wnt Signaling in Intestinal Stem Cells
Bohumil Fafilek,Michaela Krausova,Martina Vojtechova,Vendula Pospichalova,Lucie Tumova,Eva Sloncova,Martina Huranova,Jitka Stancikova,Adela Hlavata,Jiri Svec,Jiri Svec,Radislav Sedlacek,Ondrej Luksan,Martin Oliverius,Ludek Voska,Milan Jirsa,Jan Pačes,Michal Kolar,Maria Krivjanska,Klara Klimesova,Helena Tlaskalova Hogenova,Vladimir Korinek +21 more
TL;DR: Troy is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice, and functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.
Journal ArticleDOI
Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice
Lucie Tumova,Antonio R. Pombinho,Martina Vojtechova,Jitka Stancikova,Dietmar Gradl,Michaela Krausova,Eva Sloncova,Monika Horazna,Vitezslav Kriz,Olga Machonova,Jindrich Jindrich,Zbynek Zdrahal,Petr Bartunek,Vladimir Korinek +13 more
TL;DR: The data suggest monensin as a prospective anticancer drug for therapy of neoplasia with deregulated Wnt signaling with no sign of toxicity on normal mucosa is suggested.
Journal ArticleDOI
HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage–Associated Tumorigenesis
Lucie Janeckova,Vendula Pospichalova,Bohumil Fafilek,Martina Vojtechova,Jolana Tureckova,Jan Dobeš,Marion Dubuissez,Dominique Leprince,Nikol Baloghova,Monika Horazna,Adela Hlavata,Jitka Stancikova,Eva Sloncova,Katerina Galuskova,Hynek Strnad,Vladimir Korinek +15 more
TL;DR: The tumor-suppressive function of Hic1 in colon is related to its inhibitory action on proproliferative signaling mediated by the Tlr2 receptor present on tumor cells.