C
Christoph B. Westphalen
Researcher at Ludwig Maximilian University of Munich
Publications - 52
Citations - 1555
Christoph B. Westphalen is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 13, co-authored 47 publications receiving 1038 citations. Previous affiliations of Christoph B. Westphalen include German Cancer Research Center & Columbia University Medical Center.
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Journal ArticleDOI
Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling
Yoku Hayakawa,Yoku Hayakawa,Kosuke Sakitani,Mitsuru Konishi,Samuel Asfaha,Samuel Asfaha,Ryota Niikura,Hiroyuki Tomita,Bernhard W. Renz,Bernhard W. Renz,Yagnesh Tailor,Marina Macchini,Moritz Middelhoff,Zhengyu Jiang,Takayuki Tanaka,Zinaida A. Dubeykovskaya,Woosook Kim,Xiaowei Chen,Aleksandra M. Urbanska,Karan Nagar,Christoph B. Westphalen,Christoph B. Westphalen,Michael Quante,Chyuan Sheng Lin,Michael D. Gershon,Akira Hara,Chun-Mei Zhao,Duan Chen,Daniel L. Worthley,Daniel L. Worthley,Kazuhiko Koike,Timothy C. Wang +31 more
TL;DR: It is found that Dclk1+ tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa and this feedforward ACh-NGF axis activates the Gastric cancer niche and offers a compelling target for tumor treatment and prevention.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche
Yoku Hayakawa,Hiroshi Ariyama,Jitka Stancikova,Kosuke Sakitani,Samuel Asfaha,Bernhard W. Renz,Zinaida A. Dubeykovskaya,Wataru Shibata,Hongshan Wang,Christoph B. Westphalen,Xiaowei Chen,Yoshihiro Takemoto,Woosook Kim,Shradha S. Khurana,Yagnesh Tailor,Karan Nagar,Hiroyuki Tomita,Akira Hara,Antonia R. Sepulveda,Wanda Setlik,Michael D. Gershon,Subhrajit Saha,Lei Ding,Richard A. Friedman,Stephen F. Konieczny,Daniel L. Worthley,Vladimir Korinek,Timothy C. Wang,Zeli Shen,James G. Fox +29 more
TL;DR: In this article, the authors proposed a new method for cancer drug discovery based on protein-protein interactions, and obtained grants from the National Institutes of Health (U.S.) (Grants 54CA126513, R01CA093405, R1CA120979, and R1DK052778).
Journal ArticleDOI
Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030
Anne S. Quante,Chang Ming,Miriam Rottmann,Jutta Engel,Stefan Boeck,Volker Heinemann,Christoph B. Westphalen,Konstantin Strauch +7 more
TL;DR: Based on projections, pancreatic cancer will surpass colorectal and breast cancer to rank as the second most common cause of cancer‐related deaths in Germany by 2030 and liver cancer cases will show a marked increase with a continuous rise in liver cancer-related deaths.
Journal ArticleDOI
Genetically Engineered Mouse Models of Pancreatic Cancer
TL;DR: The mouse models available, their experimental use, their clinical relevance and limitations, and future directions are reviewed, including in vivo models to study innovative and alternative treatment approaches are of major importance.
Journal ArticleDOI
Repeated mutKRAS ctDNA measurements represent a novel and promising tool for early response prediction and therapy monitoring in advanced pancreatic cancer.
Stephan Kruger,Volker Heinemann,C. Ross,F. Diehl,Dorothea Nagel,Steffen Ormanns,Sibylle Liebmann,I. Prinz-Bravin,Christoph B. Westphalen,Michael Haas,Andreas Jung,T. Kirchner,M von Bergwelt-Baildon,Stefan Boeck,Stefan Holdenrieder,Stefan Holdenrieder +15 more
TL;DR: Repeated mutKRAS ctDNA measurements during follow-up appeared to be superior to protein-based tumor markers in detecting progressive disease and a powerful and highly specific tool in early response prediction and therapy monitoring of advanced PC patients receiving chemotherapy.