Alain Moreau

TL;DR: Both the prevention of AIS and the treatment of its direct underlying cause are not possible, because the definite aetiology and aetiopathogenetic mechanisms that underlie AIS are still unclear.

TL;DR: It is shown that targeted inactivation of the mouse Ptx1 gene severely impairs hindlimb development: the ilium and knee cartilage are absent and the long bones are underdeveloped, and the dual role of P TX1 revealed by the gene knockout may reflect features of the mammalian jaw and hindlimbs that were acquired at a similar time during tetrapod evolution.

TL;DR: An overview of the usefulness of nanoparticles for macrophage-mediated therapies in particular is presented and the most important parameters that affect the interaction mechanisms of the macrophages and the physicochemical aspects of the particulate systems that may influence their performance in macophage-targeted therapies are underlined.

TL;DR: In this paper, osteoblast cultures were used to test the ability of melatonin and Gpp(NH)p, a GTP analogue, to block cAMP accumulation induced by forskolin.

TL;DR: In this paper, a mouse model of mucopolysaccharidosis III type C was generated by germline inactivation of the HGSNAT gene leading to deficiency of acetyl-CoA: α-glucosaminide N-acetyltransferase involved in the lysosomal catabolism of heparan sulphate.