A
Alassane Dicko
Researcher at University of Bamako
Publications - 136
Citations - 5215
Alassane Dicko is an academic researcher from University of Bamako. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 38, co-authored 110 publications receiving 4494 citations. Previous affiliations of Alassane Dicko include National Institutes of Health & University of the Sciences.
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Journal ArticleDOI
A molecular marker for chloroquine-resistant falciparum malaria.
Abdoulaye A. Djimde,Ogobara K. Doumbo,Joseph F. Cortese,Kassoum Kayentao,Safi N. Doumbo,Yacouba Diourte,Drissa Coulibaly,Alassane Dicko,Xin-zhuan Su,Takashi Nomura,David A. Fidock,Thomas E. Wellems,Christopher V. Plowe +12 more
TL;DR: This study shows an association between the pfcrt T76 mutation in P. falciparum and the development of chloroquine resistance during the treatment of malaria, and this mutation can be used as a marker in surveillance forchloroquine-resistant falcIParum malaria.
Journal ArticleDOI
Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.
Abdoulaye A. Djimde,Ogobara K. Doumbo,Ousmane Traore,Ando B. Guindo,Kassoum Kayentao,Yacouba Diourte,Safiatou Niaré-Doumbo,Drissa Coulibaly,Abdoulaye K. Kone,Yacouba Cissoko,Mamadou Tekete,Bakary Fofana,Alassane Dicko,Dapa A. Diallo,Thomas E. Wellems,Dominic P. Kwiatkowski,Christopher V. Plowe +16 more
TL;DR: Age-adjusted comparison of subjects able to clear resistant parasites and those unable to do so provides a new phenotype for identifying host immune and genetic factors responsible for protective immunity against malaria.
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Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.
Mahamadou A. Thera,Ogobara K. Doumbo,Drissa Coulibaly,Dapa A. Diallo,Abdoulaye K. Kone,Ando B. Guindo,Karim Traore,Alassane Dicko,Issaka Sagara,Mahamadou S. Sissoko,Mounirou Baby,Mady Sissoko,Issa Diarra,Amadou Niangaly,Amagana Dolo,Modibo Daou,Sory I. Diawara,D. Gray Heppner,V. Ann Stewart,Evelina Angov,Elke S. Bergmann-Leitner,David E. Lanar,Sheetij Dutta,Lorraine Soisson,Carter L. Diggs,Amanda J. Leach,Alex Owusu,Marie-Claude Dubois,Joe Cohen,Jason N. Nixon,Aric L. Gregson,Shannon L. Takala,Kirsten E. Lyke,Christopher V. Plowe +33 more
TL;DR: Anti-AMA-1 antibodies increased significantly in both malaria vaccine groups, peaking at nearly 5-fold and more than 6-fold higher than baseline in the half-dose and full-dose groups, respectively.
Journal ArticleDOI
A Randomized Controlled Phase 2 Trial of the Blood Stage AMA1-C1/Alhydrogel Malaria Vaccine in Children in Mali
Issaka Sagara,Alassane Dicko,Ruth D. Ellis,Michael P. Fay,Sory I. Diawara,Mahamadoun H. Assadou,Mahamadou S. Sissoko,Mamady Kone,Abdoulbaki I Diallo,Renion Saye,Merepen A. Guindo,Ousmane Kante,Mohamed B. Niambele,Kazutoyo Miura,Gregory E. D. Mullen,Mark Pierce,Laura B. Martin,Laura B. Martin,Amagana Dolo,Dapa A. Diallo,Ogobara K. Doumbo,Louis H. Miller,Allan Saul,Allan Saul +23 more
TL;DR: There was a negative impact of vaccination on the hemoglobin level during clinical malaria, and mean incidence of hemoglobin <8.5 g/dL, in the direction of lower hemoglobin in the children who received AMA1-C1, although these differences were not significant after correction for multiple tests.
Journal ArticleDOI
Space-time clustering of childhood malaria at the household level: a dynamic cohort in a Mali village
Jean Gaudart,Belco Poudiougou,Belco Poudiougou,Alassane Dicko,Stéphane Ranque,Ousmane Touré,Issaka Sagara,Mouctar Diallo,Sory I. Diawara,Amed Ouattara,Mahamadou Diakite,Ogobara K. Doumbo +11 more
TL;DR: This study showed that, although infection proportions tended to decrease, high-risk zones persisted in the village particularly near temporal backwaters, and analysis of this heterogeneity at the household scale by GIS methods lead to target preventive actions more accurately on the high- risk zones identified.