A
Alejandra Tomas
Researcher at Imperial College London
Publications - 85
Citations - 2667
Alejandra Tomas is an academic researcher from Imperial College London. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 24, co-authored 71 publications receiving 1960 citations. Previous affiliations of Alejandra Tomas include University of Geneva & University College London.
Papers
More filters
Journal ArticleDOI
EGF receptor trafficking: consequences for signaling and cancer.
TL;DR: This data indicates that EGF receptor endocytic traffic can regulate signaling and cell survival and EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.
Journal ArticleDOI
Regulation of pancreatic β-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway
TL;DR: It is demonstrated that F-actin reorganization prior to insulin secretion requires gelsolin and plays a role in the glucose-dependent MAPK signal transduction that regulates β-cell insulin secretion.
Journal ArticleDOI
Targeting GLP-1 receptor trafficking to improve agonist efficacy.
Ben Jones,Teresa Buenaventura,N Kanda,Pauline Chabosseau,Bryn M. Owen,Rebecca Scott,Robert D. Goldin,N. Angkathunyakul,N. Angkathunyakul,Ivan R. Corrêa,Domenico Bosco,Paul Johnson,Lorenzo Piemonti,Piero Marchetti,A. M. James Shapiro,Blake J. Cochran,Blake J. Cochran,Aylin C. Hanyaloglu,Asuka Inoue,Tricia Tan,Guy A. Rutter,Alejandra Tomas,Stephen R. Bloom +22 more
TL;DR: It is shown that a longer plasma membrane retention time of GLP-1R results in greater long-term insulin release, which is dependent on a reduction in β-arrestin recruitment and faster agonist dissociation rates.
Journal ArticleDOI
Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis.
TL;DR: Annexins are Ca2+-binding, membrane-fusogenic proteins with diverse but poorly understood functions and it is shown that during cell cycle progression annexin 11 translocates from the nucleus to the spindle poles in metaphase and to thespindle midzone in anaphase.
Journal ArticleDOI
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.
Fabienne Jaques,Hélène Jousset,Alejandra Tomas,Anne-Lise Prost,Claes B. Wollheim,Jean-Claude Irminger,Nicolas Demaurex,Philippe A. Halban +7 more
TL;DR: It is shown that dispersed pancreatic beta-cells can respond robustly to glucose once their elevated basal secretion has been corrected, and engagement of cell adhesion molecules including E-cadherin contributes to the greater secretory response to glucose seen in cells with normal intercellular contacts.