Riccardo Sgarra

TL;DR: It is shown that, 33 months after lentiviral β-globin gene transfer, an adult patient with severe βE/β0-thalassaemia dependent on monthly transfusions since early childhood has become transfusion independent for the past 21 months.

TL;DR: The structural characteristics of the three nuclear phosphoproteins of the high mobility group A family are outlined and related to their participation in chromatin structure alteration in many biological processes such as gene expression, neoplastic transformation, differentiation, and apoptosis are outlined.

TL;DR: It is shown that HMGA2 associates with the E1A-regulated transcriptional repressor p120E4F, interfering with p120 E4F binding to the cyclin A promoter, suggesting a mechanism forHMGA2-dependent cell cycle regulation.

TL;DR: This review frame this process in the high degree of phenotypic inter- and intra-tumor heterogeneity of GBM, which exists in different subtypes, each one characterized by further phenotypesic variability in its stem-cell compartment under the selective pressure of different treatment agents PMT.

TL;DR: It is shown that the High Mobility Group A1 (HMGA1) protein plays a fundamental role in this process in basal-like breast cancer subtype, and a specific HMGA1 gene expression signature was identified that was activated in a large subset of human primary breast tumours and was associated with poor prognosis.