Alexander Heyde

TL;DR: Within individual patients, a large majority of driver gene mutations are common to all metastases, and a mathematical model of tumor evolution and metastasis formation provides an explanation for the observed driver gene homogeneity.

TL;DR: In this paper, the authors show that hematopoietic stem cell division rates are increased in mice and humans with atherosclerosis, and that increased stem cell proliferation expedites somatic evolution and expansion of clones with driver mutations.

TL;DR: Routine post-treatment sampling may have value in the management of recurrent pancreatic cancer, and it is identified that recurrent disease after adjuvant or first-line platinum therapy corresponds to an increased mutational burden.

TL;DR: In this article, a high-resolution map of the evolutionary dynamics of resistance to ICB, characterizes a de-differentiated neural-crest tumor population in melanoma immunotherapy resistance and describes site-specific differences in tumor-immune interactions via longitudinal analysis of a patient with melanoma with an unusual clinical course.

TL;DR: A mathematical model of consecutive seeding by multiple cells that relates the expected diversity of a metastasis to the diversity in the pool of seeding cells is derived and the probability that a metastases is polyclonal is calculated.