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Alexander Krasnitz
Researcher at Cold Spring Harbor Laboratory
Publications - 55
Citations - 13626
Alexander Krasnitz is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Cancer & Copy-number variation. The author has an hindex of 24, co-authored 47 publications receiving 10396 citations. Previous affiliations of Alexander Krasnitz include Stony Brook University.
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Journal ArticleDOI
Inferring tumor progression from genomic heterogeneity
Nicholas Navin,Alexander Krasnitz,Linda Rodgers,Kerry Cook,Jennifer L. Meth,Jude Kendall,Michael Riggs,Yvonne Eberling,Jennifer Troge,Vladimir Grubor,Dan Levy,Pär Lundin,Susanne Månér,Anders Zetterberg,James W. Hicks,Michael Wigler +15 more
TL;DR: In polygenomic tumors, it is shown that heterogeneity can be ascribed to a few clonal subpopulations, rather than a series of gradual intermediates, and inferred pathways of cancer progression and the organization of tumor growth are inferred.
Journal ArticleDOI
An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer
Lars Zender,Wen Xue,Johannes Zuber,Camile P. Semighini,Alexander Krasnitz,Beicong Ma,Peggy Zender,Stefan Kubicka,John M. Luk,Peter Schirmacher,W. Richard McCombie,Michael Wigler,James W. Hicks,Gregory J. Hannon,Gregory J. Hannon,Scott Powers,Scott W. Lowe,Scott W. Lowe +17 more
TL;DR: Pools of short hairpin RNAs targeting the mouse orthologs of genes recurrently deleted in a series of human hepatocellular carcinomas were compiled and 13 tumor suppressor genes were identified, 12 of which had not been linked to cancer before.
Journal ArticleDOI
Novel patterns of genome rearrangement and their association with survival in breast cancer
James W. Hicks,Alexander Krasnitz,B. Lakshmi,Nicholas Navin,Michael Riggs,Evan Leibu,Diane Esposito,Joan Alexander,Jen Troge,Vladimir Grubor,Seungtai Yoon,Michael Wigler,Kenny Ye,Anne Lise Børresen-Dale,Bjørn Naume,Ellen Schlicting,Larry Norton,Torsten Hägerström,Lambert Skoog,Gert Auer,Susanne Månér,Pär Lundin,Anders Zetterberg +22 more
TL;DR: Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer.
Journal ArticleDOI
Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
Jude Kendall,Qing Liu,Amy Bakleh,Alexander Krasnitz,Ken C. Q. Nguyen,B. Lakshmi,William L. Gerald,Scott Powers,David Mu +8 more
TL;DR: Genetic alterations that directly interfere with transcriptional networks normally regulating lung development may be a more common feature of lung cancer than previously realized.
Journal ArticleDOI
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
Wen Xue,Alexander Krasnitz,Robert Lucito,Raffaella Sordella,Linda VanAelst,Carlos Cordon-Cardo,Stephan Singer,Florian Kuehnel,Michael Wigler,Scott Powers,Lars Zender,Scott W. Lowe +11 more
TL;DR: It is shown that DLC1 knockdown cooperates with Myc to promote hepatocellular carcinoma in mice, and that reintroduction of wild-type DLC1 into hepatoma cells with low DLC1 levels suppresses tumor growth in situ.