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Alexander Krasnitz
Researcher at Cold Spring Harbor Laboratory
Publications - 55
Citations - 13626
Alexander Krasnitz is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Cancer & Copy-number variation. The author has an hindex of 24, co-authored 47 publications receiving 10396 citations. Previous affiliations of Alexander Krasnitz include Stony Brook University.
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Journal ArticleDOI
A RSC/Nucleosome Complex Determines Chromatin Architecture and Facilitates Activator Binding
Monique Floer,Xin Wang,Vidya Prabhu,Georgina Berrozpe,Santosh Narayan,Dan Spagna,David Alvarez,Jude Kendall,Alexander Krasnitz,Asya Stepansky,James W. Hicks,Gene O. Bryant,Mark Ptashne +12 more
TL;DR: The results show that both prior to and following induction, specific DNA-binding proteins are the predominant determinants of chromatin architecture at the GAL1/10 genes.
Journal ArticleDOI
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Anka Bric,Cornelius Miething,Carl Uli Bialucha,Claudio Scuoppo,Claudio Scuoppo,Lars Zender,Alexander Krasnitz,Zhenyu Xuan,Johannes Zuber,Michael Wigler,James W. Hicks,Richard W. McCombie,Michael T. Hemann,Gregory J. Hannon,Gregory J. Hannon,Scott Powers,Scott W. Lowe,Scott W. Lowe +17 more
TL;DR: In this article, short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice.
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Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
Hege G. Russnes,Hans Kristian Moen Vollan,Ole Christian Lingjærde,Alexander Krasnitz,Pär Lundin,Bjørn Naume,Therese Sørlie,Elin Borgen,Inga H. Rye,Anita Langerød,Suet-Feung Chin,Andrew E. Teschendorff,Andrew E. Teschendorff,Philip J. Stephens,Susanne Månér,Ellen Schlichting,Lars Oliver Baumbusch,Rolf Kåresen,Michael P. Stratton,Michael P. Stratton,Michael Wigler,Carlos Caldas,Carlos Caldas,Anders Zetterberg,James W. Hicks,Anne Lise Børresen-Dale +25 more
TL;DR: New algorithms are generated that can estimate the specific genomic region as well as the architectural type of rearrangement—gains or losses of chromosome arms—of breast cancer patients using array comparative genomic hybridization data to measure complex rearrangements.
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A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
Wen Xue,Thomas Kitzing,Stephanie Roessler,Johannes Zuber,Alexander Krasnitz,Nikolaus Schultz,Kate Revill,Susann Weissmueller,Amy R. Rappaport,Janelle Simon,Jack Zhang,Weijun Luo,James W. Hicks,Lars Zender,Xin Wei Wang,Scott Powers,Michael Wigler,Scott W. Lowe +17 more
TL;DR: The data imply that large cancer-associated deletions can produce phenotypes distinct from those arising through loss of a single TSG, and as such should be considered and studied as distinct mutational events.
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A tumour suppressor network relying on the polyamine–hypusine axis
Claudio Scuoppo,Cornelius Miething,Cornelius Miething,Lisa M Lindqvist,José Reyes,Cristian I. Ruse,Iris Appelmann,Iris Appelmann,Seungtai Yoon,Alexander Krasnitz,Julie Teruya-Feldstein,Darryl J. Pappin,Jerry Pelletier,Scott W. Lowe +13 more
TL;DR: The polyamine–hypusine axis is established as a new tumour suppressor network regulating apoptosis, and heterozygous deletions encompassing AMD1 and eIF5A often occur together in human lymphomas and co-suppression of both genes promotes lymphomagenesis in mice.