P
Pär Lundin
Researcher at Karolinska Institutet
Publications - 10
Citations - 3759
Pär Lundin is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Copy-number variation & Comparative genomic hybridization. The author has an hindex of 9, co-authored 10 publications receiving 3612 citations. Previous affiliations of Pär Lundin include Science for Life Laboratory.
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Journal ArticleDOI
Large-Scale Copy Number Polymorphism in the Human Genome
Jonathan Sebat,B. Lakshmi,Jennifer Troge,Joan Alexander,Janet M. Young,Pär Lundin,Susanne Månér,Hillary Massa,Megan Walker,Maoyen Chi,Nicholas Navin,Robert Lucito,John Healy,James W. Hicks,Kenny Q. Ye,Andrew Reiner,T. Conrad Gilliam,Barbara J. Trask,Nick Patterson,Anders Zetterberg,Michael Wigler +20 more
TL;DR: It is shown that large-scale copy number polymorphisms (CNPs) (about 100 kilobases and greater) contribute substantially to genomic variation between normal humans.
Journal ArticleDOI
Inferring tumor progression from genomic heterogeneity
Nicholas Navin,Alexander Krasnitz,Linda Rodgers,Kerry Cook,Jennifer L. Meth,Jude Kendall,Michael Riggs,Yvonne Eberling,Jennifer Troge,Vladimir Grubor,Dan Levy,Pär Lundin,Susanne Månér,Anders Zetterberg,James W. Hicks,Michael Wigler +15 more
TL;DR: In polygenomic tumors, it is shown that heterogeneity can be ascribed to a few clonal subpopulations, rather than a series of gradual intermediates, and inferred pathways of cancer progression and the organization of tumor growth are inferred.
Journal ArticleDOI
Novel patterns of genome rearrangement and their association with survival in breast cancer
James W. Hicks,Alexander Krasnitz,B. Lakshmi,Nicholas Navin,Michael Riggs,Evan Leibu,Diane Esposito,Joan Alexander,Jen Troge,Vladimir Grubor,Seungtai Yoon,Michael Wigler,Kenny Ye,Anne Lise Børresen-Dale,Bjørn Naume,Ellen Schlicting,Larry Norton,Torsten Hägerström,Lambert Skoog,Gert Auer,Susanne Månér,Pär Lundin,Anders Zetterberg +22 more
TL;DR: Analysis of a selected subset of clinical material suggests that a simple genomic calculation, based on the number and proximity of genomic alterations, correlates with life-table estimates of the probability of overall survival in patients with primary breast cancer.
Journal ArticleDOI
Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
Hege G. Russnes,Hans Kristian Moen Vollan,Ole Christian Lingjærde,Alexander Krasnitz,Pär Lundin,Bjørn Naume,Therese Sørlie,Elin Borgen,Inga H. Rye,Anita Langerød,Suet-Feung Chin,Andrew E. Teschendorff,Andrew E. Teschendorff,Philip J. Stephens,Susanne Månér,Ellen Schlichting,Lars Oliver Baumbusch,Rolf Kåresen,Michael P. Stratton,Michael P. Stratton,Michael Wigler,Carlos Caldas,Carlos Caldas,Anders Zetterberg,James W. Hicks,Anne Lise Børresen-Dale +25 more
TL;DR: New algorithms are generated that can estimate the specific genomic region as well as the architectural type of rearrangement—gains or losses of chromosome arms—of breast cancer patients using array comparative genomic hybridization data to measure complex rearrangements.
Journal ArticleDOI
Somatic mutagenesis in satellite cells associates with human skeletal muscle aging
Irene Franco,Anna C. V. Johansson,Karl Olsson,Peter Vrtacnik,Pär Lundin,Pär Lundin,Hafdis T. Helgadottir,Malin Larsson,Gwladys Revêchon,Carla Bosia,Andrea Pagnani,Paolo Provero,Thomas Gustafsson,Helene Fischer,Maria Eriksson +14 more
TL;DR: In satellite cells of the human leg muscle vastus lateralis, somatic mutations accumulate with age and that these mutations become enriched in exons and promoters of genes involved in muscle function.