Alexander Krasnitz

TL;DR: Using single-cell sequencing, this work comprehensively map out the facets of copy number alteration heterogeneity in a cohort of breast cancer tumors, highlighting the power of single- cell genomics in dissecting, in its many forms, intra-tumoral genetic heterogeneity of CNAs.

TL;DR: Genome-wide analysis revealed properties of CFS-like recurrent deletions that distinguish them from deletions affecting tumor suppressor genes, including their isolation at specific loci away from other genomic deletion sites, a considerably smaller deletion size, and dispersal throughout the affected locus rather than assembly at a common site of overlap.

TL;DR: It is demonstrated that sparse DNA sequencing of single-cell nuclei from prostate core biopsies is a rich source of quantitative parameters for evaluating neoplastic growth and aggressiveness, yielding novel genomic measures with the potential to improve the accuracy of diagnosis and prognosis in prostate cancer.

TL;DR: The estimated parameters suggest that breast cancer cells underwent sweepstake evolution, where only one or very few parental cells produced a descendent cell population, and the high reproduction of only a portion of cancer cells may confer high adaptability to this cancer.

TL;DR: It is determined that ROMA provides accurate and sensitive detection of duplications, amplifications, and deletions and yields defined boundaries for these events with a resolution of <50 kbp in most cases.