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Alexina Orsoni
Researcher at French Institute of Health and Medical Research
Publications - 19
Citations - 805
Alexina Orsoni is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Familial hypercholesterolemia & Lipoprotein. The author has an hindex of 13, co-authored 19 publications receiving 681 citations. Previous affiliations of Alexina Orsoni include Pierre-and-Marie-Curie University & National Institutes of Health.
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Journal ArticleDOI
A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma.
Claes Bergmark,Asheesh Dewan,Alexina Orsoni,Esther Merki,Elizabeth R. Miller,Min Jeong Shin,Christoph J. Binder,Christoph J. Binder,Sohvi Hörkkö,Ronald M. Krauss,M. John Chapman,Joseph L. Witztum,Sotirios Tsimikas +12 more
TL;DR: In this article, the content of OxPL on apoB-100 particles was measured with monoclonal antibody E06, which recognizes the phosphocholine (PC) headgroup of oxidized but not native phospholipids.
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Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia
Natacha Bellanger,Alexina Orsoni,Zélie Julia,Natalie Fournier,Eric Frisdal,Emilie Duchene,Eric Bruckert,Alain Carrié,Dominique Bonnefont-Rousselot,John Pirault,Flora Saint-Charles,M. John Chapman,Philippe Lesnik,Wilfried Le Goff,Maryse Guerin +14 more
TL;DR: It is demonstrated that the centripetal movement of cholesterol from peripheral tissues, including the vessel wall, to feces is defective in FH, thereby emphasizing its atherogenicity.
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Metabolomics Provide New Insight on the Metabolism of Dietary Phytochemicals in Rats
Anthony Fardet,Rafael Llorach,Rafael Llorach,Alexina Orsoni,Jean-François Martin,Estelle Pujos-Guillot,Catherine Lapierre,Augustin Scalbert +7 more
TL;DR: This study shows that metabolomics allows the identification of new metabolites of phytochemicals and can be used to distinguish individuals fed different phytochemical-containing foods.
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Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction.
Gregor Leibundgut,Kiyohito Arai,Alexina Orsoni,Huiyong Yin,Corey A. Scipione,Elizabeth R. Miller,Marlys L. Koschinsky,M. John Chapman,Joseph L. Witztum,Sotirios Tsimikas +9 more
TL;DR: It is demonstrated that plasminogen contains covalently bound OxPL that influence fibrinolysis and may have pathophysiological implications in AMI and atherothrombosis.
Journal ArticleDOI
Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia.
Kiyohito Arai,Alexina Orsoni,Ziad Mallat,Ziad Mallat,Alain Tedgui,Joseph L. Witztum,Eric Bruckert,Alexandros D. Tselepis,M. John Chapman,Sotirios Tsimikas +9 more
TL;DR: The impact of apheresis on Lp(a), OxPL, and Lp-PLA2 provides insights into its therapeutic benefits beyond lowering apoB-containing lipoproteins.