Ali N Dana

TL;DR: Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted.

TL;DR: The expression patterns and annotation of the genes in these three groups (Early, Middle, and Late genes) are discussed in the context of female mosquitoes' physiological responses to blood feeding, including blood digestion, peritrophic matrix formation, egg development, and immunity.

TL;DR: Despite nearly perfect preservation of synteny, there is substantial shuffling of gene order along corresponding chromosome arms in Anopheles funestus and A. gambiae, suggesting that locating genes in one anopheline species based on gene order in another may be limited to closely related taxa.

TL;DR: 23 genes encoding products likely to be involved in regulating the cellular oxidative environment and 25 insect immunity genes and 25 genes as being up or down regulated following blood feeding and/or feeding with P. berghei infected blood relative to their expression levels in sugar fed females are identified.

TL;DR: A phylogenetically broader comparative genomic analysis indicated that the most rapidly evolving proteins– those involved in immunity, hematophagy, formation of extracellular structures, and hypothetical conserved proteins– are those that probably play important roles in how mosquitoes adapt to their nutritional and external environments, and therefore could be of greatest interest in disease control.