A
Alistair R. R. Forrest
Researcher at Harry Perkins Institute of Medical Research
Publications - 184
Citations - 27204
Alistair R. R. Forrest is an academic researcher from Harry Perkins Institute of Medical Research. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 59, co-authored 175 publications receiving 23544 citations. Previous affiliations of Alistair R. R. Forrest include Griffith University & Centre for Life.
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Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response.
Stuart Aitken,Shigeyuki Magi,Ahmad M. N. Alhendi,Masayoshi Itoh,Hideya Kawaji,Timo Lassmann,Carsten O. Daub,Erik Arner,Piero Carninci,Alistair R. R. Forrest,Yoshihide Hayashizaki,Levon M. Khachigian,Mariko Okada-Hatakeyama,Colin A. Semple +13 more
TL;DR: Surprisingly, these data suggest that the earliest transcriptional responses often involve promoters generating non-coding RNAs, many of which are produced in advance of canonical protein- coding IEGs.
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The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation
Hideya Kawaji,Jessica Severin,Marina Lizio,Andrew Waterhouse,Shintaro Katayama,Katharine M. Irvine,David A. Hume,Alistair R. R. Forrest,Harukazu Suzuki,Piero Carninci,Yoshihide Hayashizaki,Carsten O. Daub +11 more
TL;DR: In FANTOM4, an international collaborative research project, a wide range of genome-scale data, including 24 million mRNA 5'-reads and microarray expression profiles along a differentiation time course of the human THP-1 cell line and under 52 systematic siRNA perturbations are collected.
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Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium
Nancy Yiu-Lin Yu,Björn M. Hallström,Linn Fagerberg,Fredrik Pontén,Hideya Kawaji,Piero Carninci,Alistair R. R. Forrest,Yoshihide Hayashizaki,Mathias Uhlén,Carsten O. Daub +9 more
TL;DR: The results show that RNA-Seq and CAGE tissue transcriptome data sets are highly complementary for improving gene model annotations and highlight biological complexities within tissue transcriptomes.
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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease.
J Kenneth Baillie,Erik Arner,Carsten O. Daub,Michiel J. L. de Hoon,Masayoshi Itoh,Hideya Kawaji,Timo Lassmann,Piero Carninci,Alistair R. R. Forrest,Yoshihide Hayashizaki,Geoffrey J. Faulkner,Christine A. Wells,Michael Rehli,Paul Pavli,Kim M. Summers,David A. Hume +15 more
TL;DR: IBD loci are strongly-enriched for monocyte-specific genes, and at least 134 additional candidate genes associated with IBD susceptibility from reanalysis of published GWA studies are identified.
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14-3-3 acts as an intramolecular bridge to regulate cdc25B localization and activity
TL;DR: Mutation of the Ser-323 site was functionally equivalent to the mutation of all three sites, resulting in the complete loss of 14-3-3 binding, increased access of the catalytic site, and access to nuclear localization sequence.