A
Allan Bradley
Researcher at Wellcome Trust Sanger Institute
Publications - 385
Citations - 81969
Allan Bradley is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 127, co-authored 379 publications receiving 77492 citations. Previous affiliations of Allan Bradley include Howard Hughes Medical Institute & University of Texas MD Anderson Cancer Center.
Papers
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Journal ArticleDOI
A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection
Amy T. Y. Yeung,Yoon Ha Choi,Yoon Ha Choi,Amy S. Lee,Christine Hale,Hannes Ponstingl,Derek Pickard,Derek Pickard,David Goulding,Mark G. Thomas,Erin E. Gill,Jong Kyoung Kim,Allan Bradley,Allan Bradley,Robert E. W. Hancock,Gordon Dougan,Gordon Dougan +16 more
TL;DR: A genome-scale CRISPR knockout library screen of THP-1 human macrophages was performed to identify loss-of-function mutations conferring resistance to Salmonella uptake, indicating a role for the relatively uncharacterized gene NHLRC2 in bothSalmonella invasion and macrophage differentiation.
Patent
Antibodies, variable domains&chains tailored for human use
TL;DR: In this article, the authors proposed a method of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies, heavy chains, polypeptides, nucleotide sequence, pharmaceutical compositions and uses.
Journal ArticleDOI
Mining the mouse genome
TL;DR: The authors have the draft sequence — but how do they unlock its secrets?
Journal ArticleDOI
Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice
Mathias J Friedrich,Lena Rad,Iraad F. Bronner,Alexander Strong,Wei Wang,Julia Weber,Julia Weber,Matthew Mayho,Hannes Ponstingl,Thomas Engleitner,Thomas Engleitner,Carolyn Grove,Anja Pfaus,Anja Pfaus,Dieter Saur,Dieter Saur,Juan Cadiñanos,Michael A. Quail,George S. Vassiliou,Pentao Liu,Allan Bradley,Roland Rad,Roland Rad +22 more
TL;DR: A large series of mouse lines for insertional mutagenesis that are compatible with two transposon systems, PiggyBac and Sleeping Beauty, are described and principles of data analysis and interpretation for obtaining insights into cancer gene function and genetic tumor evolution are described.
Journal ArticleDOI
Induced mitotic recombination of p53 in vivo
TL;DR: The induction of loss of heterozygosity in a few cells in an otherwise normal tissue mimics genetic aspects of tumorigenesis more closely than existing models and has revealed the possible cell autonomous nature of Wnt3.