Allan Bradley

TL;DR: In this paper, the authors demonstrate a crucial role for Histone deacetylase 1 and 2 in T-cell development and the maintenance of genomic stability, showing that deletion of either HDAC1 or HDAC2 alone has little effect, while dual inactivation results in a 5-fold reduction in thymocyte cellularity, accompanied by developmental arrest at the double negative to double positive transition.

TL;DR: By incorporating mouse coat color markers into the vectors, this work illustrates a widely applicable method for stock maintenance of ES cell-derived mice with single gene knockouts or more extensive chromosomal rearrangements.

TL;DR: A role for ATR is identified in the epigenetic regulation of gene expression and a new technique for ablating gene function in the germline is presented, using a novel genetic strategy in which MSCI is used to silence a chosen gene in pachytene.

TL;DR: An additional mouse model for CF has been generated that should prove useful for the understanding of the pathogenesis and the development of treatments for CF.

TL;DR: It is concluded that Prokr2 is not necessary for SCN cellular timekeeping or entrainment, but it is an essential link for coordination of circadian behavior and physiology by the SCN, especially in defining the onset and maintenance of circadian night.