A
Allan Bradley
Researcher at Wellcome Trust Sanger Institute
Publications - 385
Citations - 81969
Allan Bradley is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 127, co-authored 379 publications receiving 77492 citations. Previous affiliations of Allan Bradley include Howard Hughes Medical Institute & University of Texas MD Anderson Cancer Center.
Papers
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Journal ArticleDOI
Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.
Melissa K. Boles,Bonney Wilkinson,Laurens G. Wilming,Bin Liu,Frank J. Probst,Jennifer Harrow,Darren Grafham,Kathryn E. Hentges,Lanette S. Woodward,Andrea Maxwell,Karen Mitchell,Michael D. Risley,Randy L. Johnson,Karen K. Hirschi,James R. Lupski,Yosuke Funato,Hiroaki Miki,Pablo Marin-Garcia,Lucy Matthews,Alison J. Coffey,Anne Parker,Tim Hubbard,Jane Rogers,Allan Bradley,David J. Adams,Monica J. Justice +25 more
TL;DR: It is concluded that point mutations can be accurately and sensitively recovered by large-scale sequencing, and that conserved noncoding regions should be included for disease mutation identification.
Patent
Method for homologous recombination in animal and plant cells
TL;DR: A method for producing animal cells which contain a desired gene sequence which has been inserted into a predetermined gene sequence by homologous recombination was proposed in this article, which permits the production of animal cells that have subtle and precise modifications of gene sequence and expression.
Journal ArticleDOI
A resource of targeted mutant mouse lines for 5,061 genes
Marie-Christine Birling,Atsushi Yoshiki,David J. Adams,Shinya Ayabe,Arthur L. Beaudet,Joanna Bottomley,Allan Bradley,Allan Bradley,Steve D.M. Brown,Antje Bürger,Wendy Bushell,Francesco Chiani,Hsian-Jean Genie Chin,Skevoulla Christou,Gemma F. Codner,Francesco J. DeMayo,Francesco J. DeMayo,Mary E. Dickinson,Brendan Doe,Leah Rae Donahue,Martin Fray,Alessia Gambadoro,Xiang Gao,Marina Gertsenstein,Alba Gomez-Segura,Leslie O. Goodwin,Jason D. Heaney,Yann Herault,Martin Hrabé de Angelis,Si-Tse Jiang,Monica J. Justice,Petr Kasparek,Ruairidh King,Ralf Kühn,Ho Lee,Young Jae Lee,Zhiwei Liu,Kevin C K Lloyd,Isabel Lorenzo,Ann-Marie Mallon,Colin McKerlie,Terrence F. Meehan,Violeta Munoz Fuentes,Stuart A. Newman,Lauryl M. J. Nutter,Goo Taeg Oh,Guillaume Pavlovic,Ramiro Ramirez-Solis,Barry Rosen,Barry Rosen,Edward Ryder,Edward Ryder,Luis Santos,Joel Schick,John R. Seavitt,Radislav Sedlacek,Claudia Seisenberger,Je Kyung Seong,William C. Skarnes,Tania Sorg,Karen P. Steel,Karen P. Steel,Masaru Tamura,Glauco P. Tocchini-Valentini,Chi-Kuang Leo Wang,Hannah Wardle-Jones,Marie Wattenhofer-Donzé,Sara Wells,Michael V. Wiles,Brandon J. Willis,Joshua A. Wood,Wolfgang Wurst,Wolfgang Wurst,Ying Xu,Lydia Teboul,Stephen A. Murray +75 more
TL;DR: The International Mouse Phenotyping Consortium reported the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.
Journal ArticleDOI
Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith–Magenis syndrome
Jiong Yan,Victoria W. Keener,Weimin Bi,Katherina Walz,Allan Bradley,Monica J. Justice,James R. Lupski +6 more
TL;DR: Mouse models refined the genomic region important for a portion of the SMS phenotype and provided a basis for further molecular analysis of genes associated with SMS, indicating that the smaller deletions contain the gene(s), most likely Rai1, causing craniofacial abnormalities and obesity.
Journal ArticleDOI
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes
Jorge de la Rosa,Jorge de la Rosa,Julia Weber,Julia Weber,Mathias J Friedrich,Yang Li,Lena Rad,Hannes Ponstingl,Qi Liang,Sandra Bernaldo de Quirós,Imran Noorani,Emmanouil Metzakopian,Alexander Strong,Meng Amy Li,Aurora Astudillo,María Teresa Fernández-García,María Soledad Fernández-García,Gary J. Hoffman,Gary J. Hoffman,Rocio Fuente,George S. Vassiliou,Roland Rad,Roland Rad,Roland Rad,Carlos López-Otín,Allan Bradley,Juan Cadiñanos +26 more
TL;DR: A novel whole-body insertional mutagenesis screen in mice is developed, which was designed for the discovery of Pten-cooperating tumor suppressors, and validated ZBTB20, CELF2, PARD3, AKAP13 and WAC, which were identified by screens in multiple cancer types, as new tumor suppressor genes in prostate cancer.